routes of administration have been well documented, including avoidance of variable absorption rates and first-pass hepatic metabolism with oral delivery and improved therapeutic activity. In the past, skin penetration studies usually focused only on the physicochemical factors affecting the transport of drugs across the skin. However, recently, many researchers have also been considering the c...

BACKGROUND AND OBJECTIVES Laparoscopic sterilization (LS) is one of the most painful procedures and pain severity varies with the selected technique, being more severe when tubes are occluded with rings. Patients submitted to LS refer PO colic pain and N-butylscopolamine and sodium dipirone, for their anti-spasmodic and analgesic properties, associated to ketoprofen with anti-inflammatory prope...

The effect of adjuvant-induced arthritis on hepatic microsomal glucuronidation was studied in the rat. Arthritis was induced by injection of Mycobacterium butyricum suspended in liquid paraffin. Vmax and the Michaelis-Menten constant values for the in vitro glucuronidation of R- and S-ketoprofen, acetaminophen, and diflunisal by liver microsomes obtained from control and adjuvant-induced arthri...

BACKGROUND The association between periodontitis and atherosclerotic cardiovascular diseases (ACVD) has been established in some modestly sized studies (<10 000). Rarely, however, periodontitis has been studied directly; often tooth loss or self-reported periodontitis has been used as a proxy measure for periodontitis. Our aim is to investigate the adjusted association between periodontitis and...

Background: There are some discrepancy in association between activity of rheumatoid arthritis (RA) and periodontitis. The aim of this study was to evaluate the periodontal status of outpatients with RA. &nbsp;&nbsp; Methods: The study was conducted in 2013-14 in a rheumatology clinic in Sari, north of Iran on 74 patients with RA.&nbsp; Evaluation of RA disease activity was according to diseas...

Periodontitis is an inflammatory condition that affects the supporting tissues surrounding teeth. The occurrence of periodontitis is associated with shifts in the structure of the communities that inhabit the gingival sulcus. Although great inter-subject variability in the subgingival microbiome has been observed in subjects with periodontitis, it is unclear whether distinct community types exi...

BACKGROUND Many patients with cirrhosis have poor oral health but little is known on periodontitis, and its clinical significance is largely unknown. This study aimed to examine the prevalence and predictors of periodontitis, and evaluate the association of periodontitis with nutritional and systemic inflammation status. METHODS 145 patients with cirrhosis were consecutively enrolled. Clinica...

Aims: The main objective of the current research work is to develop liquisolid compacts BCS Class II drug ketoprofen with an intention enhance solubility by applying technique.&#x0D; Place and Duration Study: Smriti College Pharmaceutical Education between June 2018 2019.&#x0D; Methodology: Initially liquid medication was obtained dissolving in suitable solvent. Saturation studies were performe...