objective: the aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (stz)-induced diabetes mellitus). materials and methods: five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatme...

objective: in this paper, finite element model of the l4 vertebra subjected to combination of compression and flexion loading in isotropic and anisotropic cases is investigated. methods: in both cases, the vertebra is considered homogeneous. also, the body of vertebra is divided to cancellous and cortical sections in anisotropic model, but the process is assumed isotropic such as isotropic mode...

The article discusses the effect of residual stresses on fatigue strength torsion bars by using Dang Van criterion, at stress concentration root tooth and smooth part bar. Residual compressive were induced surface during technological processes cold rolling torsional pre-strain (pre-setting) to plastic range, increase elastic linear range reduce state loading. Normally, reduction in bar mountin...

The loading of cohesin onto chromatin requires the heterodimeric complex sister chromatid cohesion (Scc)2 and Scc4 (Scc2/4), which is highly conserved in all species. Here, we describe the purification of the human (h)-Scc2/4 and show that it interacts with h-cohesin and the heterodimeric Smc1-Smc3 complex but not with the Smc1 or Smc3 subunit alone. We demonstrate that both h-Scc2/4 and h-cohe...

This study reviews world literature on the strength-related effect of duration and rate of loading on wood and wood-based materials. Also, early developments are discussed which led to the currently used permanent loading factor of 9/16. Published data on duration of load are reanalyzed and compared. The comparisons suggest that the effect of stress level on duration of stress for wood is great...

Prostacyclin (prostaglandin I2, PGI2) has a variety of functions, including inhibition of smooth muscle cell proliferation, vasodilation, and antiplatelet aggregation. PGI2 production in endothelial cells has been reported to increase biphasically after shear loading, but the underlying mechanism is not well understood. To clarify the mechanism for the second phase of PGI2 upregulation, we exam...

Present paper investigated the strain and damage sensing property on concrete cubes embedded with carbon fibers. Concrete cubes of dimension 150 mm have been casted with different concentration of carbon fibers to study the strain and damage sensing property under cyclic loading that can be further used for health monitoring as non-destructive testing (NDT) approach. All the specimens were test...

In this paper, the effect of interference fit on fatigue life of holed plate of mechanical joints was investigated experimentally. Fatigue tests were carried out on the holed specimens of Al-alloy 7075-T6 alloy. The interference fit process consists of force fitting a fastener into the hole with a negative clearance (diameter of the fastener is larger than of the hole) that produces beneficial ...

Among all directions available for dislocation emission from the surface of a cylindrical circular void, the direction of the most likely emission is determined. It is shown that this direction is different from the direction of the maximum shear stress at the surface of the void due to the applied loading. The critical stress and the direction of the dislocation emission are determined for cir...

By means of the three-dimensional discrete element method, we study long-time evolution toward liquefaction state in granular materials composed spherical particles under multidirectional cyclic shearing at constant volume. Extensive simulations were carried out along 1-D linear, 2-D circular/oval, and 8-like shear paths, system was analyzed terms pore pressure, strain, texture. The macroscopic...