Impacts of plant invasions are largely scale-dependent and responses to the same exotic species may vary among communities. Since impacts caused by individual trees could anticipate consequences of a closed canopy of an invader, we studied the response of Galápagos native plants to quinine (Cinchona pubescens) trees in two vegetation zones. Quinine has invaded >11,000 ha of Santa Cruz Island, i...

In a study of intramuscular injection of quinine eight adults with moderately severe falciparum malaria resistant to chloroquine were treated with quinine dihydrochloride, being given a loading dose of 20 mg salt (16.7 mg base)/kg followed by three or four eight hourly maintenance doses of 10 mg salt (8.3 mg base)/kg injected into the anterior thigh. All patients responded to treatment. Fever a...

The fact that quinine is used to overcome uterine inertia in weak women, and as an ecbolic is always prescribed during labour, if there is no obstruction, is mainly responsible for the general impression that its use should be avoided during pregnancy as far as possible. Clinical experience, however, warrants no such fear about the administration of quinine during pregnancy. Hare, in his Practi...

Sir,?The above article in the December 1937 issue interested me very much because it raises some other points. The patient was given nine 10-grain quinine injections intramuscularly,. thrice daily and on consecutive days. In the London School of Tropical Medicine and Hygiene they condemn most emphatically intramuscular injections of quinine. They say quinine causes tissue necrosis, much of the ...

Independent experimental manipulation of subjective intensity and hedonic tone is required if one wants to study their separate effects on brain activity and behavior. This is problematic because hedonic tone and subjective intensity are related, leading to a pleasantness change each time the stimulus intensity is altered. In the present study, a solution to this problem was explored by combini...

Until now, quinine has been used worldwide as the drug of choice for the emergency treatment of severe and complicated malaria. In fact, the long­ standing dependability of quinine has created a context of clinical confidence and reduced the per­ ceived threat of P. Jalciparum recrudescence where quinine and quinidine are available. However, in a situation of substantial loss of efficacy, it is...