This paper investigates the Randomness of several Java Runtime Libraries by inspecting the integrated Pseudo Random Number Generators. Significant weaknesses in different libraries including Android, are uncovered.

Peptides have the potential for targeting vaccines against pre-specified epitopes on folded proteins. When polyclonal antibodies against native proteins are used to screen peptide libraries, most of the peptides isolated align to linear epitopes on the proteins. The mechanism of cross-reactivity is unclear; both structural mimicry by the peptide and induced fit of the epitope may occur. The mos...

A peptide that functions only in the presence of a protein has been developed using reaction-based selection from peptide phage libraries. The peptide was not functional in the absence of the protein, but formed enaminones with 1,3-diketone derivatives when bound to the protein.

In vitro peptide and protein selection using mRNA display enables the discovery and directed evolution of new molecules from combinatorial libraries. These selected molecules can serve as tools to control and understand biological processes, enhance our understanding of molecular interactions and potentially treat disease in therapeutic applications. In mRNA display, mRNA molecules are covalent...

Peptides, defined as sequences of amino acids up to approximately 50 residues in length, represent an extremely large reservoir potentially bioactive compounds, referred here the peptide chemical space. Recent advances computer hardware and software have led a wide application computational methods explore this Here, we review different silico approaches including structure-based design, geneti...