The objective of this study was to assess the performance form-based and process-based models, local-scale reach-scale used examine bank retreat sediment transport in stream restoration. evaluated models were Bank Erosion Hazard Index (BEHI), Assessment for Nonpoint Source Consequences Sediment (BANCS), Stability Toe Model (BSTEM), HEC River Analysis System (HEC-RAS 1D). Model-to-model assessme...

Ras oncoproteins are probably implicated in normal and malignant cell growth in various organs. Inhibition of Ras interferes with cell proliferation of non-hepatic cells in vitro and in vivo. A potential role for Ras in normal and malignant hepatocyte proliferation prompted us to evaluate the impact of Ras inhibition by FTS (S-farnesylthiosalicylic acid) on hepatocyte proliferation in vitro in ...

BACKGROUND Bronchiolitis obliterans syndrome (BOS) with small-airway pathology and obstructive pulmonary physiology may not be the only form of chronic lung allograft dysfunction (CLAD) after lung transplantation. Characteristics of a form of CLAD consisting of restrictive functional changes involving peripheral lung pathology were investigated. METHODS Patients who received bilateral lung tr...

Lysophosphatidic acid (LPA) is present at high concentrations in ascites and plasma of ovarian cancer patients. Studies conducted in experimental models demonstrate that LPA promotes ovarian cancer invasion/ metastasis by up-regulating protease expression, elevating protease activity, and enhancing angiogenic factor expression. In this study, we investigated the effect of LPA on ovarian cancer ...

Lysophosphatidic acid (LPA) is present at high concentrations in ascites and plasma of ovarian cancer patients. Studies conducted in experimental models demonstrate that LPA promotes ovarian cancer invasion/metastasis by up-regulating protease expression, elevating protease activity, and enhancing angiogenic factor expression. In this study, we investigated the effect of LPA on ovarian cancer m...

A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be the main cause of cancer. These mutational events include activation of oncogenes and inactivation of tumor suppressor genes. The elucidation of human cancer at the molecular level allows the design of rational, mechanism-based therapeutic ...

Recommendation agents (RAs) are software agents that elicit the interests or preferences of individual consumers for products, either explicitly or implicitly, and make recommendations accordingly. RAs have the potential to support and improve the quality of the decisions consumers make when searching for and selecting products online. They can reduce the information overload facing consumers, ...

Mouse models of cancer represent powerful tools for analysing the role of genetic alterations in carcinogenesis. Using a mouse model that allows tamoxifen-inducible somatic activation (by Cre-mediated recombination) of oncogenic K-ras(G12D) in a wide range of tissues, we observed hyperplasia of squamous epithelium located in moist or frequently abraded mucosa, with the most dramatic effects in ...

Injury, failure or success? Renin–angiotensin system inhibition in acute kidney injury Sir, The use of inhibitors of the renin–angiotensin system (RAS) in kidney disease requires that a balance be struck between long-term benefits to kidney health on the one hand and reductions in excretory function on the other. In proteinuric chronic kidney disease (CKD) management, some degree of functional ...

BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States, suggesting that novel strategies for the prevention and treatment of PDAC are urgently needed. K-ras mutations are observed in >90% of pancreatic cancer, suggesting its role in the initiation and early developmental stages of PDAC. In order to gain mechanistic insight as ...