hydraulic simulation of water flow in irrigation canals may reveal management shortcomings and help managers find solutions to them. hydraulic simulation models can be appropriate tools for understanding hydraulic behavior of irrigation systems. in the present study, the steady state hec-ras model was tested and compared with the mike 11 unsteady state model. a secondary irrigation canal in the...

Communicative moves and lexical cohesion patterns (LCPs), as mounting evidence shows, are two important indicators in writing and publishing the RAs. However, the interaction between these two crucial elements and the contribution of this interaction to the failure or success of the RAs have not been given due attention to date. Having this in mind and based on a sound theoretical framework, at...

communicative moves and lexical cohesion patterns (lcps), as mounting evidence shows, are two important indicators in writing and publishing the ras. however, the interaction between these two crucial elements and the contribution of this interaction to the failure or success of the ras have not been given due attention to date. having this in mind and based on a sound theoretical framework, at...

abstract a significant deficiency of most computer models used for stream floodplain analysis is that the locations of structures impacted by floodwaters, such as bridges, roads, and buildings, cannot be effectively compared to the floodplain location. this research presents a straightforward approach for processing output of the hec-ras hydraulic model, to enable two- and three dimensional flo...

Activating K-RAS mutations occur at a frequency of 90% in pancreatic cancer, and to date no therapies exist targeting this oncogene. K-RAS signals via downstream effector pathways such as the MAPK and the PI3K signaling pathways, and much effort has been focused on developing drugs targeting components of these pathways. To better understand the requirements for K-RAS and its downstream signali...

BACKGROUND RAS protein interactions have predominantly been studied in the context of the RAF and PI3kinase oncogenic pathways. Structural modeling and X-ray crystallography have demonstrated that RAS isoforms bind to canonical downstream effector proteins in these pathways using the highly conserved switch I and II regions. Other non-canonical RAS protein interactions have been experimentally ...

BACKGROUND Pharmacoepidemiologic analysis can confirm whether drug efficacy in a randomized controlled trial (RCT) translates to effectiveness in real settings. We examined methods used to control for immortal time bias in an analysis of renin-angiotensin system (RAS) inhibitors as the reference cardioprotective drug. METHODS We analyzed data from 3928 patients with type 2 diabetes who were r...

Abstract A significant deficiency of most computer models used for stream floodplain analysis is that the locations of structures impacted by floodwaters, such as bridges, roads, and buildings, cannot be effectively compared to the floodplain location. This research presents a straightforward approach for processing output of the HEC-RAS hydraulic model, to enable two- and three dimensional f...

K-Ras mutations are frequent in colorectal cancer (CRC), albeit K-Ras is the only Ras isoform that can elicit apoptosis. Here, we show that mutant K-Ras directly binds to the tumor suppressor RASSF1A to activate the apoptotic MST2-LATS1 pathway. In this pathway LATS1 binds to and sequesters the ubiquitin ligase Mdm2 causing stabilization of the tumor suppressor p53 and apoptosis. However, mutan...

The oncogenic function of mutant ras in mammalian cells has been extensively investigated using multiple human and animal models. These systems include overexpression of exogenous mutant ras transgenes, conditionally expressed knock-in mouse models, and somatic cell knockout of mutant and wild-type ras genes in human cancer cell lines. However, phenotypic discrepancies between knock-in mice and...