It has been reported that the mouse and the rat are susceptible to the action of plague murine toxin, whereas the rabbit is not (1). The effect of this toxin on mitochondrial respiration varies with respect to the animal species and organ from which the mitochondria are isolated. The respiration of rat heart (1) as well as rat and rabbit liver mitochondria (2) is inhibited by the toxin. In cont...

Background: Methyl 2-benzimidazole carbamate (carbendazim) is a synthetic fungicide used against organisms that cause different types of plant diseases. It is widely used as a preservative in leather, paint, textile, fruit, and paper industry. It is also used as an anticancer drug in clinical medicine. Methods: To evaluate the low dose toxicity of this compound in mammalian tissues, carbend...

objective(s) calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. in this study four novel ', 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. materials and methods four 1, 4-dihydrop...

Scaduto, Russell C., Jr., and Lee W. Grotyohann. Hydrolysis of Ca2 -sensitive fluorescent probes by perfused rat heart. Am J Physiol Heart Circ Physiol 285: H2118–H2124, 2003; 10.1152/ajpheart.00881.2001.—Rat hearts were loaded with the fluorescent calcium indicators fura 2, indo 1, rhod 2, or fluo 3 to determine cytosolic calcium levels in the perfused rat heart. With fura 2, however, basal ti...

Objective(s) Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. In this study four novel ', 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. Materials and Methods Four 1, 4-dihydropyr...

Kisspeptins, the ligands of the kisspeptin receptor known for its roles in reproduction and cancer, are also vasoconstrictor peptides in atherosclerosis-prone human aorta and coronary artery. The aim of this study was to further investigate the cardiovascular localisation and function of the kisspeptins and their receptor in human compared to rat and mouse heart. Immunohistochemistry and radiol...