background: despite the outbreak in dental science, oral and dental complications in alzheimer are of the unsolved problems. it is assumed that tumor necrosis factor-α, which is a key factor in alzheimer, has a relation with periodontal complications in patients with alzheimer disease. the present study evaluated the effect of chronic periodontitis on serum levels of tumor necrosis factor-α in ...

Background Both amyloid beta (Aβ) and tau pathologies co-exist in Alzheimer’s disease. While studies have shown that Aβ interaction results elevated AD pathology, it is not clearly understood how they might affect one another during early pathology stages leading to plaque formation. This study aimed at determining which extent a combination of gradually developing exacerbate each other the con...

sporadic alzheimer’s disease (sad) is affected by genetic risk factors, aging and oxidative stresses. the herbal extract of r. canina, t. vulgare and u. dioica has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. we investigate the neuroprotective effects of this herbal extract in the rat model of sad.  the rats were divided into control, sham, model, herbal extract...

purpose: the purpose of this study is to model cryptosporidiosis in laboratory animals. the parasites were inoculated into animalsand thenmultiplied. the process of proliferation was compared to controlcryptosporidiosis in humans. materials and methods: twenty-five laboratory mice (4-7 days of age) and twenty-five laboratory rats (5 days of age) were assigned to the category i while the categor...

Neurodegenerative diseases are progressive and incurable and are becoming ever more prevalent. To study whether neural stem cell can reactivate or rescue functions of impaired neurons in the human aging and neurodegenerating brain, we co-cultured postmortem slices from Alzheimer patients and control participants with rat embryonic day 14 (E14) neural stem cells. Viability staining based on the ...

background: acanthamoeba genus is introduced as opportunistic and cosmopoli-tan parasite. monkey and wistar rat are appropriate models for experimental study on acanthamoeba infection. in this study acanthamoeba spp. were isolated from hot spring (hs), windows dust (wd) and a corneal sample of keratitis patient (kp) and their pathogenicity surveyed by in vitro and in vivo tests. methods: isolat...