The first example of a mixed-metal amidoborane Na(2)Mg(NH(2)BH(3))(4) has been successfully synthesized. It forms an ordered arrangement in cation coordinations, i.e., Mg(2+) bonds solely to N(-) and Na(+) coordinates only with BH(3). Compared to ammonia borane and monometallic amidoboranes, Na(2)Mg(NH(2)BH(3))(4) can release 8.4 wt% pure hydrogen with significantly less toxic gases.

The glutamate transport system of the bovine renal epithelial cell line NBL-1 was studied. The Km for Na+-dependent glutamate transport was found to be 13.8 + 2.4 ,ltM (Vmax. 365 + 19.2 pmol/3 min per mg) and for Na+-dependent aspartate transport 4.5 + 1.1 ,uM (Vmax. 108 6.3 pmol/3 min per mg). The Km values are in close agreement with those expected for high-affinity Na+-dependent glutamate tr...

potassium plays an important role in improving plant tolerance to abiotic stresses such as salinity stress. to evaluate the effect of potassium on salinity tolerance of two wheat cultivars, kavir (as salt tolerant) and qods (as salt-sensitive), a pot experiment was conducted, using a factorial experiment based on randomized complete block design with three replications in different treatments (...

The effect of extracellular and intracellular Na(+) on the single-channel kinetics of Mg(2+) block was studied in recombinant NR1-NR2B NMDA receptor channels. Na(+) prevents Mg(2+) access to its blocking site by occupying two sites in the external portion of the permeation pathway. The occupancy of these sites by intracellular, but not extracellular, Na(+) is voltage-dependent. In the absence o...

      Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...

Wiele badań klinicznych wskazuje na obniżone stężenie kwasu moczowego w osoczu chorych na stwardnienie rozsiane (SR) w stosunku do grupy osób zdrowych. Podwyższenie stężenia kwasu moczowego zostało zaproponowane jako terapia leczenia chorób neurodegeneracyjnych w tym stwardnienia rozsianego ze względu na jego właściwości neuroprotekcyjne i antyoksydacyjne. Kwas moczowy jest rozpatrywany jako ma...

We compared sodium-calcium (Na-Ca) exchange in vascular smooth muscle between spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Aortic rings of 11 SHR and 11 WKY rats aged 11-12 weeks were superfused with physiological saline, and isometric tension was measured. Systolic blood pressure was higher in SHR (174 +/- 12 mm Hg) than in WKY rats (132 +/- 4 mm Hg): 1) In the presence o...

Chronic metabolic acidosis increased the Na+-H+ exchange activity in isolated renal brush-border membrane vesicles. Treatment altered the initial rate of Na+ uptake by increasing Vm (acidotic, 15.3 +/- 0.7 nmol of Na+ X mg-1 X 2 s-1; normal, 11.3 +/- 0.9 nmol of Na+ X mg-1 X 2 s-1), and not the apparent affinity KNa+ (acidotic, 10.2 +/- 0.5 mM; normal 10.2 +/- 0.6 mM). Metabolic acidosis result...

An ATP-hydrolyzing activity with the properties of a Mg(2+)-dependent (Na(+),K(+))-ATPase (ATP phosphohydrolase, EC 3.6.1.3) from a 20-fold purified plasma membrane fraction of the marine diatom, Nitzschia alba is described. The basal activity requires Mg(2+) and further stimulation by Na(+) or Na(+) plus K(+) is dependent on the presence of Mg(2+); Mn(2+) or Co(2+) can partially substitute for...