Various approaches to solvent recovery have been studied for the manufacturing process of celecoxib, the active ingredient in Celebrex. A design case study has been performed by Rowan University with Pfizer through a green engineering partnership program. The manufacturing operation at Barceloneta, Puerto Rico was evaluated and several green engineering alternatives for the purification and rec...

Leaf and woody plant tissue (Pinus ponderosa, Eucalyptus saligna, Quercus gambelli, Saccharum officinarum and Oriza sativa) were heated from 30 to 300C and volatile organic compound (VOC) emissions were identified and quantified. Major VOC emissions were mostly oxygenated and included acetic acid, furylaldehyde, acetol, pyrazine, terpenes, 2,3-butadione, phenol and methanol, as well as smaller ...

The main objective in refining units is to keep the product quality within specifications in the faces of disturbances. Online measurements of product composition using composition analyser are neither easy nor economically viable. In an effort to overcome these difficulties various soft sensors are designed in the recent years. In this research work, the authors have proposed the design of neu...

This paper considers the design and control of a reactive distillation column in which one reactant is consumed and two products are formed (A B+C). The volatilities are B ¿ A ¿ C , i.e. the reactant is intermediate boiling between the two products. The metathesis of 2-pentene is considered as the demonstrative example. The column has a single feed of the intermediate boiling reactant. The dist...

Methyl Tert-butyl Ether (MTBE) is an important chemical used as an octane booster in gasoline to replace tetra ethyl lead. Maximum production of the MTBE can be achieved using reactive distillation (RD) process at the optimum operating conditions and column configuration. However, optimizing the column configuration such as tray or catalyst location is experimentally expensive. Therefore, a rel...