The 'Recalcitrant Cancer Research Act of 2012' defines recalcitrant cancers as having a 5-year survival rate of <20% and estimated to cause the death of at least 30,000 individuals in the US each year. Cancers specifically mentioned in the act are lung and pancreatic cancers. In addition to recalcitrant tumors, rare tumors are often neglected in the drug discovery arena. Sarcomas are ~1% of can...

BACKGROUND AND AIMS Physiological epicotyl dormancy in which the epicotyl elongates inside the seed before the shoot emerges has been reported for only a few tropical rainforest species, all of which are trees that produce recalcitrant seeds. In studies on seeds of Fabaceae in Sri Lanka, we observed a considerable time delay in shoot emergence following root emergence in seeds of the introduced...

BACKGROUND Patients with severe psoriasis may be unresponsive to or unable to tolerate the adverse effects of traditional therapy. Thioguanine has been used to treat psoriasis, but experience is limited. Most previous studies have used daily therapy and have demonstrated significant hematologic abnormalities. OBJECTIVE To reduce the adverse effects of traditional thioguanine therapy, our stud...

Background: Chronic or recurrent rhinosinusitis (CRS) is a disease associated with impaired quality of life and substantial societal costs. Many cases present without a clear underlying cause and despite the lack of etiology current treatment protocols dictate intervention with antibiotics, anti-inflammatory drugs or surgery often with poor long-term outcome. Recent studies indicate that commen...

PURPOSE To report the first case to our knowledge of intravitreal daptomycin used to successfully treat culture-negative vancomycin resistant to exogenous endophthalmitis. METHODS Case report with preoperative, intraoperative, and postoperative findings. RESULTS A 63-year-old Caucasian male underwent routine pars plana vitrectomy with epiretinal membrane peeling. He developed acute postoper...