The Institute ofCancer Research receives financial support from the Cancer Research Campaign and the Medical Research Council. PJH is supported by the Cancer Research Campaign. We thank Felicity Fleetwood for typing the manuscript. 1 Hanks GW, Hoskin PJ. Opioid analgesics in the management of pain in patients with cancer. A review. Palliative Medicine 1987;1: 1-25. 2 Duthie JR, Nimmo WS. Advers...

BACKGROUND Bivalirudin has emerged as a suitable alternative anticoagulant to unfractionated heparin and low-molecular-weight heparins during percutaneous coronary intervention (PCI) procedures in the management of coronary artery disease and acute coronary syndromes (ACS). In clinical trials, bivalirudin dosing was standardized, and activated clotting time (ACT) did not influence dosing adjust...

The proposal (N4407R L2/13-110) submitted by Taichi Kawabata, et al., sought to encode six characters in the ‘Siddham’ block (U+11580), which are glyphic variants of basic characters already included in the script. The proposal was approved by WG2 at its meeting in June 2013. The Unicode Technical Committee (UTC), however, did not act upon the proposal at its meeting in July 2013. In considerat...

The basis for using information against linkage to some loci to support linkage to other loci is discussed and data on cystic fibrosis available up to late July 1985 used as an example.

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THE SCIENCE PRESS Lancaster, Pa. Garrison, N. Y. New York City: Grand Central Terminal. Annual Subscription, $6.oo. Single Copies, IS Cts. SCIENCE Is the official organ of the American Association for the Advancement of Science. Information regarding membership In the association may be secured from the office of the permanent secretary, tn the Smithsonian Institution Building, Washington, D. C...