Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ultrafiltrate. This review focuses on the molecular bi...

MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physio...

Nephrology, the study of kidney diseases, took its birth as a separate specialty many decades ago, and has gradually more in importance, especially with the advent of renal replacement therapy and kidney transplantation. Nephrology also has a strong physiology foundation; indeed an understanding of renal physiology is crucial for dealing with electrolyte and acid-base problems that a physician ...

Dr. Wu’s research interest mainly focuses on Renal Cellular Physiology and Biology, Fluid and Electrolytes disorders, Clinical Nephrology and Renal Replacement Therapy. He has been quite enthusiastic in academic pursuit and published more than 100 articles in various Journals and read more than 50 abstract in various conferences. As the result of his outstanding performance, he has been awarded...

This essay provides a summary of my professional activities. My interest in renal physiology started as a medical student in Vienna, when I became acquainted with Homer Smith's essays on kidney function. After moving to the United States in 1951, I was fortunate to be mentored by Robert Pitts, in whose Department of Physiology at Cornell Medical College in New York I was given early independenc...

for students to grasp and provides pedagogical challenge to educators. It has an inherent difficulty associated with it (intrinsic cognitive load). This inherent difficulty may not be altered by an instructor by didactic lecture or by static slides without animation (extraneous cognitive load) and it then becomes difficult for the student to understand core concepts in renal physiology like ren...