The removal of interstrand cross-links (ICLs) from DNA in higher eucaryotes is not well understood. Here, we show that processing of psoralen ICLs in mammalian cell extracts is dependent upon the mismatch repair complex hMutSbeta but is not dependent upon the hMutSalpha complex or hMlh1. The processing of psoralen ICLs is also dependent upon the nucleotide excision repair proteins Ercc1 and Xpf...

Small resting B lymphocytes all start out producing IgM Abs. Upon encountering Ag, the cells become activated and make a switch from IgM to other Ig classes. This class switch serves to distribute a particular V region to different Ig C regions. Each C region mediates a specialized effector function, and so, through switching, an organism can guide its Abs to various sites. Creating the new H c...

This paper deals with the G/G/R machining system consisting of M operating machines as well as S cold standbys. The concepts of balking and reneging are incorporated which make our model more versatile to deal with real time systems. The broken-down machines are sent to repair facilities consisting of R permanent repairmen. The failure times and repair times are generally identical and independ...

The present paper discusses the development of a Markov model for performance evaluation of coal handling unit of a thermal power plant using probabilistic approach. Coal handling unit ensures proper supply of coal for sound functioning of thermal Power Plant. In present paper, the coal handling unit consists of two subsystems with two possible states i.e. working and failed. Failure and repair...

In this paper, we develop an economic production quantity (EPQ) model under machine breakdown and two types of repair (corrective and preventive). also, study the simultaneous effect of holding safety stock and purchasing policy. In order to avoid shortages occurring as a result of the random repair time, in addition to keep safety stock, we suppose that the manufacturer could purchase some qua...

The objective of this paper is to study the M/M/R machine repair queueing system with mixed standbys. The life-time and repair time of units are assumed to be exponentially distributed. Failed units are repaired on FCFS basis. The standbys have switching failure probability q (0≤q≤1). The repair facility of the system consists of R permanent as well as r additional removable repairmen. Due to i...

background : denture fracture is an unresolved problem in complete denture prosthodontics. however, the repaired denture often experiences a refracture at the repaired site due to poor transverse strength. hence, this study was conducted to evaluate the effect of joint surface contoursand glass fiber reinforcement on the transverse strength of repaired acrylic resins. materials and methods: a t...

Mutations are introduced into rearranged Ig variable genes at a frequency of 10(-2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair. Therefore, hypermutation was studied in mice deficient for either the DNA nucleotide excision r...