1 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 2 Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio 3 Department of Electrical and Computer Engineering and Biomedical Engineering Institute, Old Dominion University, Norfolk, Virginia 4 Department of Radiology, Case Western Reserve University, Cleveland, Ohio 5 Department o...

Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white adipose tissue) and BAT (brown adipose tissue). WAT stores energy and is the largest energy reserve in mammals, whereas BAT, expressing UCP1 (uncoupling protein 1), can dissipate energy through adaptive thermogenesis. In rodents, ample e...

Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a decreased physiological reserve in response to stress (termed homeostenosis) and a time-dependent failure of complex molecular mechanisms that cumulatively create disorder. Aging inevitably occurs with time in all organisms and emerges on a molecular,...

With the adoption of combination antiretroviral therapy (ART), most HIV-infected individuals in care are on five or more medications and at risk of harm from polypharmacy, a risk that likely increases with number of medications, age, and physiologic frailty. Established harms of polypharmacy include decreased medication adherence and increased serious adverse drug events, including organ system...

The population of the developed world is steadily ageing. In the European Union, approximately 22% of persons are over 60 years of age and this is projected to increase to more than 27% by the year 2020. This has major implications for health care resources and the productive workforce. Ageing is accompanied by a decline in the physiological reserve of all organ systems, compromising homeostasi...

Plant carotenoids are synthesized and accumulated in plastids through a highly regulated pathway. Lycopene β-cyclase (LCYB) is a key enzyme involved directly in the synthesis of α-carotene and β-carotene through the cyclization of lycopene. Carotenoids are produced in both carrot (Daucus carota) leaves and reserve roots, and high amounts of α-carotene and β-carotene accumulate in the latter. In...

this paper extends the scope of algebraic computation based on a non standard × to the more basic case of a non standard +, where standard means associative and commutative. two physically meaningful examples of a non standard + are provided by the observation of motion in special relativity, from either outside (3d) or inside (2d or more), we revisit the “gyro”-theory of ungar to present the m...

background and aims: there are different causes for brain death including head trauma, cerebrovascular accidents and intracranial space-occupying lesions. the present study was aimed to determine the causes of brain death in chahar mahal and bakhtiari province due to high turnover of trauma in this area during 2003 to 2013. methods: this study was based on routine data and was conducted on all ...

Objective: First Nations people in Canada often migrate between living “on-reserve” and “off-reserve.” The purpose of this study was to determine if there was any difference in birth outcomes among First Nations women living on-reserve versus off-reserve in Manitoba. Study Design: This population-based birth cohort study was conducted using Statistics Canada’s linked vital data for Manitoba, 19...

Background: Although maximal sprint speed (MSS) and the anaerobic speed reserve (ASR) provides valuable information about the speed profile of athletes, these parameters fall short of providing important information about sub-maximal metabolic thresholds. The only field test that can offer an estimate of a sub-maximal metabolic threshold is the 3-minute all-out test for running (3MT) which deli...