The discovery that aerobic exercise increases adult hippocampal neurogenesis and can enhance cognitive performance holds promise as a model for regenerative medicine. This study adds two new pieces of information to the rapidly growing field. First, we tested whether exercise increases vascular density in the granular layer of the dentate gyrus, whole hippocampus, and striatum in C57BL/6J mice ...

New neurons are continuously generated in the adult hippocampus but their function remains a mystery. The nestin thymidine kinase (nestin-TK) transgenic method has been used for selective and conditional reduction of neurogenesis for the purpose of testing the functional significance of new neurons in learning, memory and motor performance. Here we explored the nestin-TK model on a hybrid genet...

Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Several toxin-induced animals models simulate the motor deficits occurring in PD. Among them, the unilateral 6-hydroxydopamine (6-OHDA) model is frequently used in rats and has the advantage of presenting side-biased motor impairments. However, the behavioral consequences of a unilateral 6-OHDA-lesion have, so far, ...

characterized by epileptic seizures, which are evoked by unexpected, high-level neuronal discharges in the brain. Since the anticonvulsant agents currently used in the treatment of epilepsy have certain disadvantages such as notable side effects and inefficient therapy in some seizure types, a clear need for safer and more effective antiepileptic drugs is well known. Therefore the development o...

putative activity of hydroalcoholic and aqueous infusion extracts of echium amoenum l. was investigated in mice using the rotarod model of motor coordination and the elevated plus maze model of anxiety. the extracts were administered intraperitonealy (i.p.) once, one hour before performing the tests. preliminary phytochemical study of the plant, with standard procedures, showed that it contains...

Ethanol-induced motor incoordination and subacute ataxia are widely reported. Damage to cerebellar Purkinje cells has not been described as a constant finding in studies addressing the alcoholic brain nor in experimental studies. The present study aimed to find out the changes in the count of cerebellar Purkinje cells and tests of motor coordination following chronic ethanol exposure in adult m...

The effect of a new conjugate hydroxybenzoic acid with glycine on sensory-motor and cognitive impairments in experimental animals chronic cerebrovascular insufficiency (CCI) was studied. CCI modeled rats by stenosis thelumen the carotid arteries 60 %. 40 days after operation, groups were formed test compound administered for 14 days. Citicoline used as reference drug, saline placebo. After trea...

Neuroligin 2 (NLGN2) is a postsynaptic adhesion protein that plays an essential role in synaptogenesis and function of inhibitory neuron. We previously identified a missense mutation R215H of the NLGN2 in a patient with schizophrenia. This missense mutation was shown to be pathogenic in several cell-based assays. The objective of this study was to better understand the behavioral consequences o...

The swimming endurance test, anoxic tolerance and basal activity by actophotometer were used to assess the antistress of a seven-day therapy (200 400 mg/kg, p.o.) ethanolic extract Coriandrum sativum (EECS) aerial parts. A method for measuring in vitro antioxidant hydroxyl radicals was used. In all examined models, at both doses demonstrated effects. duration stay on rotarod, EECS treated rats ...