objective: it is hypothesized that stem cells have the capability to form tumors after transplantation. spermatogonial stem cells have proliferation potency and colonization ability related to express pluripotency genes such as c-myc. the primary aim of this study is to investigate tumorigenicity ability of these cells after in vitro cultivation and inoculation in athymic animals. methods: sper...

objective(s): in this study, the effect of electrospun fiber orientation on proliferation and differentiation of mesenchymal stem cells (mscs) was evaluated. materials and methods: aligned and random nanocomposite nanofibrous scaffolds were electrospun from polylactic acid (pla), poly (vinyl alcohol) (pva) and calcium carbonate nanoparticles (ncap). the surface morphology of prepared nanofibrou...

the incidence of traumatic brain injury (tbi) are annually increasing, developed tissue engineering methods could represent the definite remedies for patients with strongly injured central nervous system and have a great effect in the public healthcare cost. the current clinical treatments in tbi display several limitations. furthermore, several therapies, coming from neural tissue engineering ...

background: the aim of this study was to fabricate the poly caprolactone (pcl) aligned nanofiber scaffold and to evaluate the survival, adhesion, proliferation, and differentiation of rat hair follicle stem cells (hfsc) in the graft material using electrospun pcl nanofiber scaffold for tissue engineering applications. methods: the bulge region of rat whisker was isolated and cultured in dmem: n...

background: stem cell factor (scf) is a transcriptional factor which plays crucial roles in normal proliferation, differentiation and survival in a range of stem cells. objective: the aim of the present study was to examine the proliferation effect of different concentrations of scf on expansion of human endometrial cd146+ cells. materials and methods: in this experimental study, total populati...

introduction: bone marrow (bm) is a known source of mesenchymal stem cells (mscs) that are used for cell therapy. this study attempts to identify if the wharton’s jelly (wj) is a suitable substitute for bm as a source for mscs. materials and methods: a population of human wj and bm stem cells were isolated and incubated with fluorescein conjugated antibodies for five specific msc markers. cell ...

The stem cell marker nestin is an intermediate filament protein that plays an important role in cell integrity, migration, and differentiation. Nestin expression occurs in approximately one third of pancreatic ductal adenocarcinoma (PDAC), and its expression strongly correlates with tumor staging and metastasis. Little is known about the mechanisms by which nestin influences PDAC progression. H...

 Dental Pulp Stem Cells (DPSCs) can be found within the cell rich zone of dental pulp. These stem cells, under specific stimuli, differentiate into many cell types which have wide therapeutic applications.   The dental stem cells are derived from both deciduous and permanent teeth. The viable dental stem cells are very simple to collect, without any mortality and morbidity. Dental pulp stem c...

objective: multiple myeloma (mm) is a plasma cell malignancy where plasma cells are increased in the bone marrow (bm) and usually do not enter peripheral blood, but produce harmful factors creating problems in these patients (e.g. malignant plasma cells over activate osteoclasts and inhibit osteoblasts with factors like rankl and dkk). these factors are a main cause of bone lesion in mm patient...