Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance. We describe here an array-based technique to identify proteins undergoing glutathionylation and apply it to the secretome and the proteome of human monocytic cells. The method is based on incorporation of biotinylated glutathione (GSH) i...

Staphylococcus aureus protein A (SpA) is the most popular affinity ligand for immunoglobulin G1 (IgG1). However, the molecular basis for the dissociation dynamics of SpA-IgG1 complex is unclear. Herein, coarse-grained (CG) molecular dynamics (MD) simulations with the Martini force field were used to study the dissociation dynamics of the complex. The CG-MD simulations were first verified by the...

in this paper, the synchronization of a new hyperchaotic complex system based on t-s fuzzy model is proposed. first the considered hyperchaotic system is represented by t-s fuzzy model equivalently. then by using the parallel distributed compensation (pdc) method and by applying linear system theory and exact linearization (el) technique, a fuzzy controller is designed to realize the synchroniz...

In this paper, we are discuss about the issue of synchronization for singular complex dynamical networks with Markovian jumping parameters and additive time-varying delays through pinning control by Takagi-Sugeno (T-S) fuzzy theory.The complex dynamical systems consist of m nodes and the systems switch from one mode to another, a Markovian chain with glorious transition probabili...

Objective(s): Studies have indicated advantageous properties of [DOTA-DPhe1 , Tyr3 ] octreotide (DOTATOC) in tumor models and labeling with gallium. Breast cancer is the second leading cause of cancer mortality in women, and most of these cancers are often an adenocarcinoma. Due to the importance of target to non-target ratios in the efficacy of diagnosis, the pharmacokinetic of 68Ga-DOTATOC in...

introduction: developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. in this work, sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. methods: sm-153 chloride was obtained by thermal neutron flu...