نتایج جستجو برای: scleroderma

تعداد نتایج: 7035  

Journal: :Medicinski arhiv 2011
Amira Dedic Adisa Pasalic Mia Hodzic Semsa Basovic Mersiha Avdic Enes Pasic

Modern etiopathogenic and diagnostic procedures of oral diseases are founded on molecular biology, genetic engineering, autoimmunity, pathohistological, cytological and immunofluorescence methods. The autoimmune processes may include the humoral and cellular immune responses and all organ systems may be involved. The systematic and orofacial manifestations of the scleroderma with medical and pa...

2008
Erdal Yekeler Nesrin Gürsan

Scleroderma is a generalized autoimmune disease with variable involvement of the skin and major organs (esophagus, lung, heart and kidney). Scleroderma is essentially a skin disease that frequently involves the digestive system. In scleroderma, the esophagus is the most frequently affected organ of the digestive system, and esophageal dysmotility, reflux and stricture may be observed in the adv...

Journal: :The British journal of ophthalmology 1979
R H West A J Barnett

Thirty-eight patients with scleroderma (progressive systemic sclerosis) without renal failure were subjected to detailed clinical ophthalmic assessment. Abnormalities were frequent. However, many of these, including lens opacities, vitreous frosting, and arteriosclerotic changes, were considered to be age-related, and there were various incidental changes. Posterior subcapsular lens opacities i...

 Subcutaneous calcinosis consists of abnormal calcium deposition in soft tissues and is one of the complications of scleroderma, especially in limited systemic sclerosis. It is one of the criteria of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia). A 44-year-old woman with systemic scleroderma for 20 years was presented with pain ...

2012
Armando Gabrielli Silvia Svegliati Gianluca Moroncini Donatella Amico

Systemic sclerosis (Scleroderma - SSc) is a connective tissue disorder of unknown aetiology characterized by extensive fibrosis of the skin and visceral organs, by vascular abnormalities and immunological manifestations.Recent evidence suggest that the cellular redox state may play a significant role in the progression of scleroderma fibrosis. Mechanisms involved include an autoamplification ci...

Journal: :Reumatologia clinica 2014
Senol Kobak Servet Hacivelioglu Selen Gungor

This paper presented a 28-year-old female with systemic sclerosis who developed scleroderma renal crisis and ovarian hyperstimulation syndrome following clomiphene administration. Urgent therapy including angiotensin-converting enzyme (ACE) inhibitors and supportive care resulted in regression and eventually resolution of all the clinical and laboratory symptoms. Although scleroderma renal cris...

Journal: :Alternative medicine review : a journal of clinical therapeutic 2006
Alan R Gaby

Scleroderma is an autoimmune disease of the connective tissue characterized by fibrosis and thickening of various tissues. It can be limited to the skin or affect multiple organs, and its course ranges from slowly to rapidly progressive. Penicillamine, glucocorticoids, and other drugs are used to treat scleroderma, but none of these treatments has a high degree of efficacy. This article reviews...

2013
Taeko Nakamura-Wakatsuki Toshiyuki Yamamoto

Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relati...

Journal: :Rheumatic diseases clinics of North America 2008
Sandeep K Agarwal Filemon K Tan Frank C Arnett

It currently is believed that scleroderma is a complex polygenic disease that occurs in genetically predisposed individuals who have encountered specific environment exposures and/or other stochastic factors. The nature of these genetic determinants and how they interact with environmental factors are areas of active investigation. This article discusses the evidence that supports a strong gene...

Journal: :Rheumatology 2008
M Trojanowska

PDGF functions as a primary mitogen and chemoattractant for cells of mesenchymal origin. Members of the PDGF family play an important role during embryonic development and contribute to the maintenance of connective tissue in adults. Deregulation of PDGF signalling has been linked to atherosclerosis, pulmonary hypertension and organ fibrosis. Elevated expression of PDGF and its receptors has be...

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