Background: Adequate pain management is an essential entity in reconstructive surgery to prevent adverse physiological and psychological outcome. Transdermal buprenorphine has been mostly studied chronic cancer related but hardly studies acute are available. Aims Objectives: The aims of this study were compare post-operative relief achieved by transdermal IV paracetamol terms safety efficacy. S...

INTRODUCTION We investigated the potential benefits of early tracheotomy performed before day eight of mechanical ventilation (MV) compared with late tracheotomy (from day 14 if it still indicated) in reducing mortality, days of MV, days of sedation and ICU length of stay (LOS). METHODS Randomized controlled trial (RCT) including all-consecutive ICU admitted patients requiring seven or more d...

upper endoscopy is a common procedure for the diagnosis and treatment of upper digestive tract diseases. the increasing number of pediatric gastrointestinal procedures has led to increasing attention on the safety and efficacy of medications used for sedation during the procedure. this randomized blinded interventional study was designed to compare the effect of oral midazolam with intravenous ...

Significant changes in topographic quantitative EEG (QEEG) features were documented during induction and emergence from anaesthesia induced by the systematic administration of sevoflurane and propofol in combination with remifentanil. The goal was to identify those changes that were sensitive to alterations in the state of consciousness but independent of anaesthetic protocol. Healthy paid volu...

Veterinarians are faced with clinical challenges every day with the goal of solving diagnostic dilemmas, reducing morbidity and mortality, and ultimately restoring patient health. One of the most challenging issues we face is determining the best sedation and/or anesthesia protocol for the sick, small animal patient. The objective of this lecture is to provide a clinical tool for understanding ...

1. Interpret factors affecting the acute and long-term psychological well-being of the critically ill. 2. Design initiatives to prevent agitation, pain, and delirium and the development of post-traumatic stress disorder in intensive care unit (ICU) patients. 3. Design effective strategies to optimize pharmacologically based ICU patient comfort while avoiding therapeutic misadventures. 4. Apprai...

Transcatheter aortic valve replacement is increasingly performed as a minimally invasive treatment option for aortic valve disease. The typical anesthetic management for this procedure was traditionally similar to surgical aortic valve replacement and involved general anesthesia and transesophageal echocardiography. In this review, we discuss the technological advances in transcatheter valve sy...

The treatment of fearful or anxious patients presents a myriad of problems for the dentist. In-office sedation using oral (enteral) medications is an effective means of increasing patient tolerance of invasive dental procedures. The incremental oral administration technique is a protocol that can be utilized to treat fearful or anxious patients. A case is presented in which this technique was u...

BACKGROUND Sedation practice, especially when non-anaesthesia personnel are involved, requires efficient anaesthetic depth monitoring. Therefore, we used prediction probability (PK) to evaluate the performance of the bispectral index (BIS) of the EEG and automated responsiveness test (ART) to predict sedation depth and loss of subject's responsiveness during propofol sedation, with and without ...

INTRODUCTION Sedation is widely used in intensive care unit (ICU) patients to limit the risk of pulmonary barotrauma and to decrease oxygen needs. However, adverse effects of cc5128sedation have not been fully evaluated; in particular, effects of benzodiazepine and opiates on microcirculation have not been extensively studied. The aim of this study was to evaluate the microcirculatory effects o...