Background: In intracavitary brachytherapy for gynecological cancers, various techniques are used to locate the anterior rectal wall nearest to the sources but there is no consensus on the best method to do so. This study aimed to compare a technique used routinely in some centers that employs a wire marker to locate the position of the maximum rectal dose point, versus the method recommended b...

The formation of continuous patterns of nanostructured materials using directed self-assembly under external fields has generated considerable current research interest. We demonstrate for the first time such continuous patterning by inducing irreversible self-assembly leading to nucleation in mesocopic materials (inorganic, organic, and nanoparticles) using a tightly focused laser beam in an o...

For decades, classical crossover studies and linkage disequilibrium (LD) analysis of genomic regions suggested that human meiotic crossovers may not be randomly distributed along chromosomes but are focused instead in "hot spots." Recent sperm typing studies provided data at very high resolution and accuracy that defined the physical limits of a number of hot spots. The data were also used to t...

We train a convolutional neural network, APOGEE Net, to predict $T_\mathrm{eff}$, $\log g$, and, for some stars, [Fe/H], based on the spectra. This is first pipeline adapted these data that capable of estimating parameters in self-consistent manner not only low mass (such as main sequence dwarfs, pre-main and red giants), but also high stars with $T_\mathrm{eff}$ excess 50,000 K, including hot ...

Meiotic recombination, crucial for proper chromosome segregation and genome evolution, is initiated by programmed DNA double-strand breaks (DSBs) in yeasts and likely all sexually reproducing species. In fission yeast, DSBs occur up to hundreds of times more frequently at special sites, called hot spots, than in other regions of the genome. What distinguishes hot spots from cold regions is an u...

We present a technique for creating a longitude-resolved image of Jupiter’s thermal radio emission. The technique has been applied to VLA data taken on 25 January 1996 at a wavelength of 2 cm. A comparison with infrared data shows a good correlation between radio hot spots and the 5 μm hot spots seen on IRTF images. The brightest spot on the radio image is most likely the hot spot through which...

Bone scintigraphy is widely used to detect bone metastasis owing to its high sensitivity, but solitary focus of increased uptake often causes diagnostic problem because of its low specificity. The purpose of this study was to assess the significance of solitary hot spot detected in patients with extraskeletal malignancies. We reviewed 1,167 consecutive bone scintigraphies of patients with histo...

MOTIVATION Hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy. These residues are critical in understanding the principles of protein interactions. Experimental studies like alanine scanning mutagenesis require significant effort; therefore, there is a need for computational methods to predict hot spots in protein interfac...

background and aims: one of the most common approach to understanding spatial and temporal trends of event data is to break it up into a series of time snapshots. therefore space-time cube method applied in order to portray the likely trend in occurrence of the pulmonary tuberculosis (tb) cases. methods: in this study, information of all patients with pulmonary tb recorded in surveillance syste...