Psychological, physiological, and biochemical studies were conducted on 4 healthy young-adult males while they underwent 120 hr. of sleep deprivation. The subjects quickly Formed a group and dealt with this contrived stress in much the same way that groups cope with stressful environments. Although it is concluded that sleep deprivation is stressful, our measurements did not show an adrenocorti...

Several pieces of evidence suggest that sleep deprivation causes marked alterations in neurotransmitter receptor function in diverse neuronal cell types. To date, this has been studied mainly in wake- and sleep-promoting areas of the brain and in the hippocampus, which is implicated in learning and memory. This article reviews findings linking sleep deprivation to modifications in neurotransmit...

BACKGROUND The purpose of this study was to examine the effect of sleep deprivation on flow experience. METHODS Sixteen healthy male volunteers of mean age 21.4±1.59 (21-24) years participated in two experimental conditions, ie, sleep-deprivation and normal sleep. In the sleep-deprived condition, participants stayed awake at home for 36 hours (from 8 am until 10 pm the next day) beginning on ...

M.T. Bianchi (ed.), Sleep Deprivation and Disease: Effects on the Body, Brain and Behavior, DOI 10.1007/978-1-4614-9087-6_2, © Springer Science+Business Media New York 2014 Paradigms of sleep deprivation, sleep restriction, and sleep fragmentation have been utilized to answer fundamental questions about sleep, including how much sleep adults need and the defi cits and recuperation associated wi...

OBJECTIVE Bright light therapy is effective and well tolerated in seasonal affective disorder and some studies reported an antidepressant effect of bright light also in non-seasonal depression. On the other hand, total sleep deprivation leads to a rapid and marked improvement of mood in 60% of depressed patients. Combinations of antidepressant medication with those somatic therapies are general...

Chronically painful conditions are frequently associated with sleep disturbances, i.e. changes in sleep continuity and sleep architecture as well as increased sleepiness during daytime. A new hypothesis, which has attracted more and more attention, is that disturbances of sleep cause or modulate acute and chronic pain. Since it is well-known that pain disturbs sleep the relationship between the...

Previous research suggests that sleep deprivation may heighten normal reactions to an aversive social encounter. In this study, we explored how 24 h of sleep deprivation may influence responses to ostracism. Ninety-six healthy young adults were randomly allocated to either the sleep-deprivation or well-rested condition, wherein they engaged in two rounds of a ball-tossing game (Cyberball) progr...

Many of the factors affecting the success of haematopoietic cell transplantation are still unknown. Here we show in mice that donor sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconstitute the blood and bone marrow of an irradiated recipient by more than 50%. We demonstrate that sleep deprivation downregulates the expression of microRNA (miR)-19b...

According to a survey conducted in 2007, 35-40% of adult U.S population chronically restricts their sleep on less than 7 hours on weekday nights, compared with 8-9 hours to maintain brain normal function during the day. Studies have demonstrated that sleep deprivation reduces the capabilities and efficiency of performance by impairing perception, increasing effort to keep concentrate, as well a...