The long-term efficacy and safety of sodium valproate and carbamazepine in adult outpatients with newly diagnosed primary generalised or partial and secondarily generalised seizures were compared in a randomised, open, multicentre study at 22 neurology outpatient clinics. Patients were randomised to oral sodium valproate (Epilim EC enteric coated 200 mg tablets twice daily, n = 149) or oral car...

This study reports the results of an open trial of Sodium Valproate in tardive-dyskinesia. Fifteen patients identified having tardive dyskinesia by two psychiatrists independently were treated with Sodium Valproate in dosage of 1200 mg/day for 4 weeks. Assessments were made on abbreviated Dyskinesia Scale. There was statistically significant improvement after 2 and 4 weeks of treatment. Authors...

cally appearing after her HD sessions. At that time she was treated with postdilutional HDF, with 20 l infusate per 4.5-hour session, FX80 dialyzer (helixone, 1.8 m 2 , Fresenius Medical Care, Bad Homburg, Germany), blood flow 300 ml/min, AVF as vascular access. Valproate concentrations were measured before and after HDF approximately every 2 weeks and were 666 8 53 (range 567–750, therapeutic ...

background: omega-3 polyunsaturated fatty acids (pufa) have beneficial effects on both specific and non-specific inflammatory reactions. the aim of this study was to evaluate the effect of dietary supplementation with fish oil in migraine prevention. methods: a 12-week, randomized, single-blind clinical trial was conducted from october 2008 to june 2009. a total of 67 patients (52 women, 15 men...

Introduction: Epilepsy is a clinical syndrome in which seizures have a tendency to recur. Sodium valproate is the most effective drug in the treatment of all types of generalized seizures. Finding the optimal dosage (the lowest effective dose) of sodium valproate is a real challenge to all neurologists. In this study, a new approach based on Adaptive Neuro-Fuzzy Inference System (ANFIS) was pre...

BACKGROUND Post-herpetic neuralgia is difficult to treat. Divalproex sodium (valproic acid and sodium valproate in molar ratio 1:1) has been used successfully in the management of various painful neuropathies. AIM To study the effectiveness and safety of divalproex sodium in the management of post-herpetic neuralgia. DESIGN Randomized double-blind placebo-controlled trial. METHODS We enro...

Autism is a complex alteration in children’s developing nervous system that manifests behavioral patterns do not match those of typical subjects. Moreover, starting at puberty, these children may encounter problems regarding social interaction related to sexual encounters. As studies are scarce, we used the valproate model autism zebrafish contribute knowledge behavior this disorder. Young were...

UNLABELLED AIM. This study was designed to examine whether the class I and class IIa histone deacetylase (HDAC) inhibitors, sodium butyrate and sodium valproate alter the expression of human NCOR1 and/or NCOR2 genes coding for N-CoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptors), respectively. METHODS Human leukemia HL-60 cells were tre...