Background: Even though, Pseudomonas aeruginosa is a common cause of hospital-acquired infections, treatment challenging because decreasing rates susceptibility to many broad-spectrum antibiotics. Methods: Consumption data eight broad spectrum antimicrobial agents and resistance P. were collected for 48 consecutive months. Autoregressive integrated moving average (ARIMA) transfer functions mode...

Background & Aims: Acinetobacter spp. are non-fermenting gram-negative coccobacilli that have emerged in recent three decades as major causes of nosocomial infections. Acinetobacter baumannii is the most common pathogen causing a wide spectrum of infections. Acinetobacter infections are difficult to treat, due to both the intrinsic resistance of the pathogen and its ability to readily acquire n...

background and objective: pseudomonas aeruginosa has become a frequent cause of nosocomial infections, particularly in intensive care units (icus). many reports have documented high rates of resistance in this species to commonly-used broad-spectrum antibiotics. the aim of this study was to assess the in vitro activity of some antibiotics against pseudomonas aeruginosa strains to determine the ...

Introduction Urinary tract infections (UTIs) pose a serious health problem for patients with high cost to society. UTIs are also the most frequent healthcare associated infections. E. coli is the predominant pathogen in uncomplicated UTIs. Besides E. coli, other Enterobacteriaceae, Enterococcus spp, and Pseudomonas aeruginosa are also cultured in patients with urological diseases. Microbial res...

background extended-spectrum beta-lactamases (esbls) are a group of enzymes that hydrolyze antibiotics, including those containing new cephalosporins, and they are found in a significant percentage of escherichia coli and klebsiella pneumoniae strains. with the widespread use of antibiotics, difficulties with infection therapy caused by drug resistant organisms, especially those that have acqui...

Soon after broad spectrum antibiotic drugs became available for therapy, reports appeared in the literature describing moniial infections of the anogenital area and oral mucosa. Cannon (1) reported on the considerable amount of attention being centered upon the problem of the rising frequency of monilial infections in relation to antibiotic therapy. Loh and Baker (2) studied the fecal flora of ...

We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages. Ex vivo stimulation of leukocytes with either of the antibiotics (0.04-40 mg/L) significantly increased IL-8 secretion. Incubation of...