Human guanylate-binding protein 1 (hGBP1) is a key player in innate immunity and fights diverse intracellular microbial pathogens. Its antimicrobial functions depend on hGBP1’s GTP binding- hydrolysis-induced abilities to form large, structured polymers attach lipid membranes. Crucial for both of these biochemical features the nucleotide-controlled release C terminally located farnesyl moiety. ...

Structural  design  optimization  usually  deals  with  multiple  conflicting  objectives  to  obtain the minimum construction cost, minimum weight, and maximum safety of the final design. Therefore, finding the optimum design is hard and time-consuming for  such problems.  In this paper, we borrow the basic concept of multi-criterion decision-making and combine it with  Particle  Swarm  Optimi...

One of the main tasks of engineers is to design structural systems light and economic as possible, yet resistant enough to withstand all possible loads arising during their service life and to absorb the induced seismic energy in a controlled and predictable fashion. The traditional trial-and-error design approach is not capable to determine an economical design satisfying also the code require...