The aim of this study was to analyze the effect of Okadaic Acid (OA) on the proliferation of gastric and colon epithelial cells, the main target tissues of the toxin. We hypothesized that OA, at sublethal doses, activates multiple signaling pathways, such as Erk and Akt, through the inhibition of PP2A. To demonstrate this, we carried out curves of doses and time response against OA in AGS, MKN-...

Fenpyroximate (FP), an acaricide, is widely used in the prevention of acarids (mites) in fruit plant gardens. In this study, the acute toxic effects of sublethal concentrations of FP were investigated using adult guppy (Poecilia reticulata PETERS, 1859). Guppy adults were exposed to sublethal FP concentrations (15, 25, and 150 μgl) during 48 hours (n:10). Sublethal exposures were made according...

Data are presented demonstrating the differential radiosensitivity of the first and second-set responses of sublethally irradiated (670 rad) mice previously sensitized with allogeneic (H-2 difference), xenogeneic (rat) or both allogeneic and xenogeneic skin grafts: The secondset response is more radioresistant than is the first-set response; the second-set response to a xenogeneic graft remains...

BACKGROUND The standard treatment of epithelial ovarian cancer is tumor debulking by surgery, followed by six cycles of chemotherapy consisting of cisplatinum and paclitaxel. However, this therapy protocol is not satisfactory, since about 50% of the treated patients eventually experience recurrence within a few years of follow-up. Thus, a more innovative treatment modality is urgently needed fo...

We examined the effect of two avocadofurans, 2-(pentadecyl)furan and 2-(heptadecyl)furan, from avocado idioblast oil cells on maturation and larval feeding behavior of a generalist insect herbivore, Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae). Experiments were conducted using two larval sizes: early-stadium larvae refer to those larvae from experiments initiated with neonates while late...

The responses of three recA-dependent operons (recA, lambda, and phi 80), with three different repressors, to five DNA damage treatments were compared. Each operon shows a unique induction onset time constant over a wide dose range. However, the extent of response is variable within the same dose range. Individual Escherichia coli cells show a graded SOS response to different levels of DNA dama...

Current bee population declines and colony failures are well documented yet poorly understood and no single factor has been identified as a leading cause. The evidence is equivocal and puzzling: for instance, many pathogens and parasites can be found in both failing and surviving colonies and field pesticide exposure is typically sublethal. Here, we investigate how these results can be due to s...

The increased urinary excretion of citrate following administration of sodium bicarbonate has been noted by many investigators (l-9). During the course of work on the effect of uranium on various metabolic processes we wished to ascertain whether the kidney poisoned by uranium would excrete citrate to the same extent that a normal kidney does after administration of sodium bicarbonate. Surprisi...

Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 cGy, while the number of blood forming stem cells (CFUs) in the pre-irradiated ...