Triple combination therapy with hydroxychloroquine, sulfasalazine, and methotrexate (MTX) has been shown in double-blind, placebo-controlled studies to be significantly superior to MTX alone (Paulus 50% responses of 77% versus 33%). In long-term follow-up studies, this therapy has now been shown to be well-tolerated with continued efficacy in the majority of patients.

Introduction Pediatric chronic nonbacterial osteomyelitis (CNO) is a sterile inflammatory bone disorder in which innate and adaptive immunity dysfunction involved. Unifocal and multifocal disease courses are known. The modern treatment modalities include non-steroid anti-inflammatory drugs (NSAIDs), steroids, sulfasalazine (SSZ), methotrexate (MTX), bisphosphonates and biologic drugs TNFa and I...

A 35 year old female with JIA was diagnosed at eighteen months, initially oligoarticular, extending to a polyarticular pattern, with steroid dependent bilateral anterior uveitis necessitating immunosuppression. She received Abatacept infusions between December 2012 and July 2013. She had received numerous previous disease modifying agents including Sulfasalazine, Methotrexate, Hydroxychloroquin...

Background: An animal study revealed that sulfasalazine (SSZ) enhances Pneumocystis clearance from the lung by accelerating macrophage activity.[1] Although preventive effect of SSZ on pneumonia (PCP) in patients with rheumatoid arthritis (RA) is reported case-control studies, some important confounders might remain unmeasured and distort results. [2-3]. The self-controlled case series (SCCS) m...

Transporter gene knockout rats are practically advantageous over murine models for pharmacokinetic and excretion studies, but their phenotypic characterization is lacking. At present, relevant aspects of pharmacokinetics, metabolism, distribution, and excretion of transporter probes [P-glycoprotein (P-gp): loperamide and paclitaxel; breast cancer resistance protein (Bcrp): sulfasalazine; and mu...