نتایج جستجو برای: sulphonamide
تعداد نتایج: 542 فیلتر نتایج به سال:
2-Methylquinazolin-4(3H)one; Urea; Thiourea; Sulphonamide derivatives; Anti-inflammatory; Antimicrobial activity Abstract A variety of novel 2-methylquinazolin-4(3H)-one derivatives (1–29) bearing urea, thiourea and sulphonamide functionalities at position 3 of biological interest have been synthesized and screened for their anti-inflammatory (TNF-a and IL-6) and antimicrobial activities (antib...
In 1944 a schoolboy, then aged thirteen, was wounded slightly in the right foot by a nail, which caused a moderate lymphangitis of the leg. A month before, while running, he had felt his right leg give way momentarily. A few days after the injury to his foot, while he was bathing in the sea and already recovered from the trauma, he suffered a sudden pain in the right groin which increased rapid...
Reduced glutathione (GSH) is one of the most preferred biological substrates of myeloperoxidase-derived hypochlorous acid and is a likely target for neutrophil oxidants. We have used HPLC to show that the oxidation of GSH by hypochlorous acid gives two major, stable products in addition to glutathione disulphide (GSSG). The most prevalent product lacks free amine and thiol groups, and was shown...
1. After intravenous injection about 30% of the dose (20mg./kg.) of succinylsulphathiazole is excreted unchanged in the bile in 3hr. by the rat, whereas only about 1% is excreted by the rabbit. When the renal pedicles are ligated the biliary excretion of succinylsulphathiazole in the rat increases to about 80% of the dose, but in the rabbit under these conditions the biliary excretion is only 2...
Trimethoprim (2,4,diamino-5-(3',4',5'-trimethoxybenzyl) pyrimidine) is an antifolic acid agent developed by workers at the Wellcome Research Laboratories (Hitchings, Elion, Falco, Russell, Sherwood, and Vanderwerff, 1950a, b). It was found to inhibit the enzyme dihydrofolic acid reductase in bacteria with little or none of this activity against the corresponding enzymes of mammalian species (Hi...
OBJECTIVES The objective of this study was to determine the distribution and genetic basis of trimethoprim resistance in Actinobacillus pleuropneumoniae isolates from pigs in England. METHODS Clinical isolates collected between 1998 and 2011 were tested for resistance to trimethoprim and sulphonamide. The genetic basis of trimethoprim resistance was determined by shotgun WGS analysis and the ...
It is believed that there are many practitioners and public health officers who would now employ a reasonably efficient oral therapy in gonorrhoea in preference to penicillin by injection, even though penicillin rates highly on the score of cost. It may well be that after 10 years the chance of an untoward penicillin reaction will become much greater, even in places where such reactions are now...
[This corrects the article on p. 113 in vol. 81.].
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