This study has selected the medium-chain saturated fatty acid pelargonic as raw material for first time, and added surface catalyst Tween 80 to aqueous solution form acid–Tween composite vesicles by a tension method. The compound vesicle was used encapsulate five heterocyclic drugs (cefazolin sodium, chlorpromazine hydrochloride, gemcitabine metronidazole, isoniazid), all of which have disadvan...

Triptoreline is a potent agonist of luteinizing hormone-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Frequent injection of drug decreases patients’ compliance. The present study describes the formulation of a sustained release microparticulate drug delivery system containing triptoreline acetate, using poly (D,L lacti...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...

   The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...

We investigate the pharmacokinetics of two different cephalexin formulations administered to llamas by the intravenous (IV), intramuscular (IM), and subcutaneous (SC) routes, the minimum inhibitory concentration (MIC) of cephalexin against some Escherichia coli and staphylococci isolated from llamas, and we apply the PK/PD modelling approach, so that effective dosage recommendations for this sp...

Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties maximum therapeutic efficacy. The regulates the rate at which is released. Because it facilitates prolonged release, major excipient in formulation retardant. technology may promote patient compliance efficiently treat chronic illnesses by d...

An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For ...

Background and purpose of study: In the present investigation, an attempt was made to increase therapeutic effectiveness, reduce dose frequency and improvement in patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using tamarind gum as release modifier. Methods: Six batches of sustained release matrix tablets of Diclofenac sodium were prepared by using diffe...

The objective of this work was to develop sustained release formulation for hydrophilic drugs with minimal burst effects. For this purpose, nanoparticles of a hydrophilic drug were produced using supercritical CO2, which were then encapsulated into polymer microparticles using an anhydrous method, followed by studying their sustained in-vitro drug release. A hydrophilic drug, dexamethasone phos...