THE RISE IN total body oxygen consumption after severe thermal injury r-04 is accompanied by an increase in visceral oxygen utilization and substrate turnover, in part to meet the metabolic demands of the wound (1). The 4 increased heat production after injury is the consequence not of altered thermoregulatory drives, but of an elevated metabolic state (2). The extent of this increased heat pro...

Previous studies have indicated that substitution of chromosome 13 of the salt-resistant Brown Norway BN/SsNHsdMcwi (BN) rat into the genomic background of the Dahl salt-sensitive SS/JrHsdMcwi (SS) rat attenuates the development of salt-sensitive hypertension and renal damage. To identify the regions within chromosome 13 that attenuate the development of hypertension during a high-salt diet in ...

This study determined the hemodynamic effects of chronic ethanol in telemetered freely moving age-matched spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Changes in blood pressure (BP), heart rate (HR), and plasma norepinephrine (as index of sympathetic activity) were evaluated in pair-fed rats receiving liquid diet with or without ethanol (5%, w/v) for 12 weeks. The SHRs exhibite...

PURPOSE The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, we analyzed the changes in gene expression induced by the ketogenic diet in the rat kainic acid (KA) epilepsy model. MATERIALS AND METHODS KA-administered rats were fed the ketogenic diet or a normal diet for 4 weeks, and microarray analysis was...

Vitamin A is required for reproduction and normal embryonic development. We have determined that all-trans-retinoic acid (atRA) can support development of the mammalian embryo to parturition in vitamin A-deficient (VAD) rats. At embryonic day (E) 0.5, VAD dams were fed purified diets containing either 12 micrograms of atRA per g of diet (230 micrograms per rat per day) or 250 micrograms of atRA...

The nature and distribution of neutral sterols has been determined in the digestive tract of adult Large White sows maintained in a defined biological steady state (constant weight: 70 +/- 5 kg). The semi-synthetic diet contained 0.08 p. 100 cholesterol. Cholesterol was the main sterol of the intestinal contents. From the caecum, it was partially transformed into coprostanol (less than 6 p. 100...

The stroke-prone spontaneously hypertensive rat (SHRSP) showed an exaggerated response to a high-fat, high-cholesterol (HFC) diet, and the resulting reactive hypercholesterolemia was suggested to exacerbate the atherogenic process in this rat. We thus performed a quantitative trait locus (QTL) analysis on the serum cholesterol level of SHRSP before and after the HFC diet, with the final goal be...