BACKGROUND Diagnosis of tuberculosis (TB) remains problematic despite many new advanced diagnostic methods. A reliable and rapid diagnostic test, which could be performed in any standard pathology laboratory, would help to obtain definitive early diagnoses of TB. In the present study we describe a prospective evaluation for demonstrating Antigen (Ag) 85 complex in the sera from TB patients. M...

HIV-associated tuberculosis (HIV-TB) remains a global public health challenge, with the major burden being borne by countries in low-resource settings. If World Health Organization targets to reduce TB deaths by 95% and new cases by 90% are to be met by 2035, major improvements in diagnostic strategies are among the most pressing needs. HIV coinfection presents particular challenges in the diag...

Introduction: It is estimated that one-third of the world’s population is infected with M. tuberculosis. Also we came to know that the numbers of TB cases are on the rise in our rural based tertiary care hospital. We searched for Mycobacterium tuberculosis antigen in the serum of patients with pulmonary TB by developing Sandwich ELISA. Materials & Methods: We took 50 pulmonary TB patients, 50 d...

n Society ht cense. Abstract Background: It is difficult to diagnose tuberculosis (TB) in dialysis patients because of the high rate of extrapulmonary TB in these patients compared with the general population. Recently, a new diagnostic test called QuantiFERON(QFT) has been developed and shown promise as a diagnostic tool for active TB diseases and latent TB infection. The aim of the present st...

multidrug-resistant (mdr) and extensively drug-resistant (xdr) tuberculosis (tb) are increasing globally. treatment options for these patients are very limited. although treatment of these patients with standardized regimen is associated with high mortality and morbidity, rational usage of new drugs might be promising. in this study we will review epidemiology of xdr-tb and tdr-tb in iran and t...

The high incidence of multidrug-resistant tuberculosis (MDR-TB) in the community due to lack socialization or provision health education about MDR-TB. During this time, is only focused on (TB) generally. purpose study was determine effect behavior MDR-TB prevention patients with pulmonary two Community Health Centers Padang. This design quasi-experimental pre and post-test groups only. program ...

BACKGROUND The release of interferon-gamma (IFN-γ) by T lymphocytes increases after rechallenge with Mycobacterium tuberculosis antigen, especially, at a localized site of tuberculosis (TB) infection. We aimed to compare the clincial efficacy of two commercial IFN-γ release assays from pleural fluid for the diagnosis in tuberculous pleurisy. METHODS We performed T-SPOT.TB and QuantiFERON-TB G...

BACKGROUND Although the tuberculin skin test (TST) is frequently used to aid in the diagnosis of tuberculosis (TB) disease and to identify persons with latent TB infection, it is an imperfect test and approximately 10-25% of persons with microbiologically confirmed TB disease have a negative TST. Previous studies have suggested that persons with a negative TST are more likely to present with se...