Background: OH (occult hernias) refer to those hernias which are not evident on clinical examination, but noted either surgical exploration or good quality pre-operative imaging. Identifying them in day-to-day practice is of immense importance view unexplained and undiagnosed symptomatology, post-operative recurrences cost effectiveness. The main objective this paper study the incidence occult ...

A Phase I trial of thiotepa (TT) administered as an i.v. bolus was performed in 19 children with refractory malignancies. The starting dose was 25 mg/m2 with escalations to 50, 65, and 75 mg/m2. Seven additional patients were treated with 8-h infusions at 50 or 65 mg/m2. The maximum tolerated bolus dose was 65 mg/m2. Reversible myelosuppression was the dose-limiting toxicity. The plasma and cer...

Case report A 38 year old white man was admitted to another hospital with left sided pleuritic chest pain with effusion (January 1974). Two previous episodes of pleurisy with effusion had occurred in March 1972 and November 1973, both ofwhich cleared spontaneously. Both episodes were of unknown aetiology. The patient denied any weight loss, chills, fevers, cough, haemoptysis, or abdominal or jo...

Attempts to utilize pharmacologically active agents to close the fallopian tubes date back at least to 1849 when Froriep reported passing a cannula transcervically to the uterine tubal ostia and cauterizing the tubal lumen with a nitric acid-coated probe.14 Salgado reported in 194 1 that Brazilian midwives lavaged the uterine cavity with a mixture of tincture of iodine and carbolic acid as a co...

We describe the development of a pediatric outpatient transplant program and our initial experience with autologous and allogeneic transplants performed partially or completely in the outpatient setting. Forty-eight autologous and seven allogeneic transplants have been performed in our institution in the outpatient setting between June 1994 and July 2000. The ablation used for the autologous ou...

In a study recently published in Annals of Oncology, Coombes et al. [1] reported the results of a prospective randomized trial comparing a short course of anthracycline-containing chemotherapy followed by high-dose chemotherapy with stemcell support (HDCT) versus a conventional-dose anthracyclinecontaining chemotherapy (CDCT) as adjuvant treatment in breast cancer patients with four or more pos...

A Phase I trial of thiotepa (II) administered as an i.v. bolus was performed in 19 children with refractory malignancies. The starting dose was 25 mg/m2 with escalations to 50, 65, and 75 mg/nr. Seven additional patients were treated with 8-h infusions at 50 or 65 mg/m2. The maximum tolerated bolus dose was 65 mg/m2. Reversible myelosuppression was the dose-limiting toxicity. The plasma and cer...

Translation elongation factor 1P (EF-lP) catalyzes the exchange of bound GDP for GTP on EF-la. The lethality of a null allele of the TW5 gene encoding EF-lP in Saccharomyces cerevisiae was suppressed by extra copies of the TW2 gene encoding EF-la. The strains with tefs::TRPl suppressed by extra copies of TEF2 were slow growing, cold sensitive, hypersensitive to inhibitors of translation elongat...