The present study aims to examine the influence of Quercetin (QR) in testis of Streptozotocin (STZ)induced diabetic rats. Diabetes was induced by a single injection of STZ (65 mg/kg, ip). Quercetin (25 and 50 mg/kg/day) was treated to normal and diabetic rats for 5 weeks. In serum, glucose, testosterone, Interleukin-6 (IL-6), Interleukin-1beta (IL-1β) and Tumor Necrosis Factor-α (TNF-α) levels ...

One of the rarest varieties of intrascrotal neoplasm is a tumor composed of striated muscle. Only a few cases have been published and most of these appear as isolated reports in the older foreign literature. In many cases, the tumor was closely connected with the testicle, but it was difficult to determine whether it arose from the testis or from the adjacent tissue. Rokitansky in 1849 describe...

Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplemen...

Germinal damage is an almost universal accompaniment of cancer treatment as the result of bystander damage to the testis from cytotoxic drugs and/or irradiation. Cancer treatment for the most common cancers of the reproductive age group in men has improved such that most are now treated with curative intent, and many others are treated with likelihood of prolonged survival, so that the preserva...

Introduction: Diabetes mellitus has adverse effects on male sexual and reproductive functions in human and animals. Diabetes results in reduced fertility and libido. Medicinal plants have attracted much attention in controlling many diseases such as diabetes. In the present study, we aimed to investigate the effect of garlic juice on testicular damage. Methods: Forty male rats (250±20) wer...

AIM To evaluate the immunohistopathological changes in the contralateral testis of rats after an experimental spermatic cord torsion. METHODS Male Sprague-Dawley rats of 45-50 days old were subjected to a 720 degree unilateral spermatic cord torsion for 10, 30 and 80 days (experimental group, E), respectively or sham operation (control group, C). Histopathology of the contralateral testis as ...

The present study was aimed to analyse the effect of acrylamide and Hybanthus enneaspermus leaf extract active principles on mice testis glutathione-s-transferases (GST; EC 2.5.1.18). These enzymes play a role in biotransformation of electrophilic compounds that cause damage to cells by conjugating with the substrate glutathione. Hybanthus enneaspermus, a spade flower, is an erect shrub of viol...

Cancer treatments, either chemo- or radiotherapy, may cause severe damage to gonads which could lead to the infertility of patients. In post-pubertal male patients, semen cryopreservation is recommended to preserve the potential to have their own biological children in the future; however, it is not applicable to prepubertals. The preservation of testis tissue which contains spermatogonial stem...

Leukocytes, specifically macrophages, lymphocytes and mast cells, are found within the testes of most, if not all, mammals. In some species (for example, rats, mice and humans), the number of 'resident' testicular macrophages, in particular, is quite considerable. However, reproductive biologists are only beginning to explore the characteristics and possible biological significance of these cel...