This case demonstrates the benefits of luspatercept for thalassemic patients who are unable to receive adequate blood transfusions. It acts as a selective ligand trap and inhibits TGF- signaling via Smad2/3 promote differentiation maturation late-stage erythroid precursors. Phase III clinical data showed that 33% reduction in transfusion burden from baseline was achieved. The administration cha...

Effect of the leaves suspension Cassia occidentalis on elimination excess iron from artificially overloaded rabbits was studied. Leaves C. (250mg/kg) were used for rabbits. Rabbits divided into three groups; five weeks and then treated with selected herb four weeks. Iron concentrations in serum body organs like heart, liver kidneys assayed all groups after overloading jectosol plus injections a...

Background: Thalassaemia is an emerging global public health concern. It considering as a rapidly growing major burden for low- and middle income countries. The prevalence of thalassaemia increasing in Bangladesh, indicates that thalassemia will be our country. Objective: To assess the level mental stress among parents with thalassemic child. Materials Methods: A cross-sectional study was condu...

eleven goat breeds of different origin (10 spanish and 1 african) were considered for this study: zambian dwarf, azpi-gorri, blanca-andaluza, blanca-celtibérica, blanca de rasquera, catalana, malagueña, moncaína, murciano-granadina, negra serrana and pyrenean. nine linear body measurements for females, as well as the body weight ratio between gender and body weight, were obtained from literatur...

The mechanisms underlying Plasmodium falciparum resistance in persons with sickle trait have been under active investigation for more than a half century. This Perspective reviews progress in solving this challenging problem, including recent studies that have exploited the genomics and proteomics of the parasite. The formation of Hb S polymer in the parasitized AS RBC leads to impaired parasit...

The mechanisms underlying Plasmodium falciparum resistance in persons with sickle trait have been under active investigation for more than a half century. This Perspective reviews progress in solving this challenging problem, including recent studies that have exploited the genomics and proteomics of the parasite. The formation of Hb S polymer in the parasitized AS RBC leads to impaired parasit...