نتایج جستجو برای: therapeutic antibody
تعداد نتایج: 505122 فیلتر نتایج به سال:
INTRODUCTION Radioimmunotherapy (RIT) with 90Y-labeled anti-CD66 antibody is used to selectively irradiate the red marrow (RM) before blood stem cell transplantation of acute leukemia patients. To calculate the activity to administer, time-integrated activity coefficients are required. These are estimated prior to therapy using gamma camera and serum measurements after injection of 111In labele...
Antibodies provide a suitable tool in fundamental research and their high affinity and specificity make them invaluable for diagnostic and therapeutic applications. A promising alternative to conventional antibodies are the heavy chain antibodies (VHH) of Camelidae having short length, high solubility and stability are preferred to other antibody derivatives. In this study, our goal was product...
Background and Objectives: Rituximab is an anti-CD20 chimeric monoclonal antibody widely used for the treatment of malignant B cells lymphoma. However, the immunogenicity of murine-derived monoclonal antibodies and the large size of full length antibodies restrict cancer immunotherapy. Humanized single chain antibodies can be a solution and a promising alternative for application in immunothera...
Background: Bispecific antibodies represent an important class of mAbs, with great therapeutic potentials due to their ability to target simultaneously two distinct epitopes. The generation of functional bispecific antibodies with the highest possible yields is particularly critical for the production of these compounds on industrial scales. Anti- CD3 × CD19 bsAb is a bispecific T-cell engager ...
We compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences when blind-testing 15 samples. Calibration relation to reference reagent and standard curve obtained by a dilution series reduced inter-laboratory variability ca 10-fold. The harmonisation quantification ...
New approaches for immunotherapy based on nanodiamond particles have been developed. The possible ways of conjugate synthesis comprising antibody as targeting vector, carrier, chlorine e6 photosensitizer, demonstrated. Spectral-luminescent properties the conjugates studied. It has shown that obtained effectively binds to cells in vitro. was observed immobilized ND reveals its photodynamic activ...
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