Alzheimer's disease (AD) progresses from a preclinical period, through a middle phase of cognitive deterioration, to a late, profound state. The temporal progression of disability can be modeled with a horologic (time-based) function using "time-index" (TI) intervals (day- or year-units) to quantify an individual's disability across multiple cognitive and functional domains relative to a refere...

The analysis of gene expression profiles, obtained from DNA microarray experiments, is used to discover relationships between genes and to discern groups of genes involved common processes. The principal aim of this paper is to introduce dynamic modelling of microarray time course data. A novel approach to identify similar gene expression profiles is presented. Using parametric modelling, we de...

-1INTRODUCTION Halfway through the twentieth century, linguistics underwent a major methodological shift, from distributional analysis of native-speaker speech (BloomÞeld, 1961), to the analysis of native-speaker intuitions about legal sentence types (Chomsky, 1957; for reviews, see Newmeyer, 1980; Sells, Shieber & Wasow, 1991). In most cases, the native speakers who furnish these intuitions ha...

We report the results from five experiments employing a modified version of the short-term visual matching (STVM) method introduced by Driver and Baylis (1996). In STVM, participants see a study display with ambiguous figure-ground relations. After the study display, participants have to decide which of two shapes in a match display was seen before in the study display. STVM has been used by Ve...

Time series data on biochemical reactions reveal transient behavior, away from chemical equilibrium, and contain information on the dynamic interactions among reacting components. However, this information can be difficult to extract using conventional analysis techniques. We present a new method to infer biochemical pathway mechanisms from time course data using a global nonlinear modeling tec...

abstract   background and purpose: traditional lecture-based teaching has been long used to transit theoretical knowledge to the participants. due to some problems of this didactic approach, some believe that integration within an active method is more valuable in nursing education. in this study, we hypothesized that integrating lecture-based teaching within clerkship course would enhance nurs...

This research investigates the process by which people understand metaphors . We apply processing distinctions from computational models of analogy to derive predictions for psychological theories of metaphor . We distinguish two classes of theories: those that begin with a matching process (e.g Gentner & Clement, 1988 ; Ortony, 1979) and those that begin with a mapping process (e.g. Gluckserg ...

The time course of the impedance changes caused by the contralateral acoustic reflex was investigated in five normal hearing, young adult subjects The acoustic reflex function was measured with equipment having a time constant of 15 milliseconds which permitted precise temporal measures. Temporal intervals from signal onset and termination to various portions of the acoustic reflex function wer...