Physalis peruviana L. (Cape gooseberry) is a member of the Solanaceae family widely used in traditional medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatoid arthritis. Extracts of this plant have showed relevant antioxidant and anti-inflammatory activities (Wu et al. 2006; Franco et al. 2007). The aim of the current study was to investigate the anti-inflammatory e...

ETHNOPHARMACOLOGICAL RELEVANCE Intestinal microflora plays crucial roles in modulating pharmacokinetic characteristics and pharmacological actions of active ingredients in traditional Chinese medicines (TCMs). However, the exact impact of altered intestinal microflora affecting the biotransformation of TCMs remains poorly understood. AIMS OF THE STUDY This study aimed to reveal the specific e...

Abstract Background Despite the increased morbidity of ulcerative colitis (UC) in developing countries, available treatments remain unsatisfactory. Therefore, it is urgent to discover more effective therapeutic strategies. Pulsatilla chinensis was widely used for treatment inflamed intestinal diseases including UC thousands years China. Anemoside B4, most abundant triterpenoid saponin isolated ...

Intestinal fibrosis is a debilitating complication of Crohn’s disease (CD) patients. Our groups and others discovered that intestinal metabolites are associated with fibrosis. We selected the most relevant determined their anti-fibrogenic efficacies in three mouse models compared metabolite profiles between non-IBD, stricturing CD, non-stricturing CD patients inflammatory bowel (IBD) multi-omic...

We performed this study to develop a reliable method for inducing colitis in rats using 2,4,6-trinitrobenzene sulfonic acid (TNBS) to reduce the variation in ulcer size. A pair of ring forceps was used to clamp the colon and 0.1 M TNBS in ethanol was injected into the luminal side of the clamped portion. This method resulted in a small coefficient of variation of the ulcer index. A significant ...

Anti-inflammatory and anti-nociceptive properties of endocannabinoids and synthetic cannabinoid compounds were described previously. We studied effects of the endogenous cannabinoid anandamide (N-arachidonylethanolamine) in experimental colitis induced by TNBS (2,4,6-trinitrobenzene sulfonic acid) in AKR mice. A scoring system was used to describe clinical and macroscopic changes. Intraperitone...

An increased omega-3 polyunsaturated fatty acid (n-3 PUFA) tissue status can lead to a significant formation of anti-inflammatory lipid mediators and effective reduction in inflammation injury murine colitis. Arachidonic lipoxygenases (ALOX) have been implicated the pathogenesis inflammatory bowel disease as well pro- mediators. To explore role Alox15 protective response found fat1 transgenic m...

We have previously shown that complement factor 5a (C5a) plays a role in the pathogenesis of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats by using the selective, orally active C5a antagonist AcF-[OP(d-Cha)WR]. This study tested the efficacy and potency of a new C5a antagonist, hydrocinnamate (HC)-[OP(d-Cha)WR], which has limited intestinal lumenal metabolism, in this model...

Chronic pancreatitis (CP) is a devastating disease characterized by persistent and uncontrolled abdominal pain. Our lack of understanding is partially due to the lack of experimental models that mimic the human disease and also to the lack of validated behavioral measures of visceral pain. The ligand-gated cation channel transient receptor potential ankyrin 1 (TRPA1) mediates inflammation and p...