New carborane anions carrying one or three triflyloxy substituents are described. The mono-triflyloxy substituted carborane can be halogenated to give pentabromo and decachloro derivatives with preservation of the B-OTf linkage. The use of [HCB11Cl10OTf](-) as a weakly coordinating anion is demonstrated.

objective(s):glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. glutathione s-transferases (gsts) are members of multigenic family, which have important role in cells as an antioxidant. in the present study, we examined the polymorphism of gstt1 and gstm1 deletion genotypes (t0m1, t1m0, and t0m0) in 100 glaucoma patients (41with pr...

Multiphoton microscopy has been shown to be a useful tool in studying drug distribution in biological tissues. In addition, fluorescence lifetime imaging provides information about the structure and dynamics of fluorophores based on their fluorescence lifetimes. Fluorescein, a commonly used fluorescent probe, is metabolized within liver cells to fluorescein mono-glucuronide, which is also fluor...

The fluorinated dendritic chiral mono-N-tosylated 1,2-diphenylethlenediamine, FTsDPEN, has been synthesized and applied in the ruthenium(ii) complex-catalyzed asymmetric transfer hydrogenation of prochiral ketones in aqueous media.

Regioselective nucleophilic addition of electron rich aromatics to the beta-position of acetal carbon of p-benzoquinone mono O,S-acetal was achieved by modifying the acetal moiety.

OBJECTIVES The purpose of this study was to evaluate flexural strengths, moduli, and maximum deflection of Clearfil AP-X (APX) and Ceram-X Mono (CXM) when cured with a quartz-tungsten halogen (QTH) or an LED-light (LED). METHODS Specimens were made according to ISO 4049 and cured with QTH or LED for 10, 20 or 60s. Flexural strength, modulus, and deflection were determined after 24 h water sto...

The utility of W-alkylidene complexes for enyne ring-closing metathesis is demonstrated in a direct comparison with Mo-based analogs. Tungsten complexes lead to less alkyne oligomerization and higher levels of endo-selectivity and enantioselectivity.

Novel synthetic approach to mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside was attained from the coupling of lithiated 2,4-dimethoxy-6-methylpyrimidine with 1-benzyloxy-3-(tert-butyldiphenylsilyloxy)propan-2-one, followed by the sequential reactions of methylthiomethylation, cyclization, hydroxylation, and dealkylation.

Glutathione S-transfenase activities have been identified in the small intestine of the rat. Thmreeactivities obtained with p-nitrobenzyl chloride (aralkyl), 1,2-epoxy-3-(p-nitro phenoxy)propane (epoxide), and ethacrynic acid (alkene) as substrates were present in significant amounts. Gel filtra tion indicated an elution volume for the intestinal transfer ase activities that was similar to thos...

The assembly of the lipid-linked core oligosaccharide Glc3Man9GlcNAc2, the substrate for N-linked glycosylation of proteins in the endoplasmic reticulum (ER), is catalyzed by different glycosyltransferases located at the membrane of the ER. We report on the identification and characterization of the ALG12 locus encoding a novel mannosyltransferase responsible for the addition of the alpha-1,6 m...