abstract  introduction: hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. with c onsidering the potential anti-diabetic effect of the medicinal plant withania somnifera (ws)( ashwagandha), this study was designed to investigate the analgesic effect of ws on formalin-induced nociceptive responses (standard formali...

Angiotensin-converting enzyme (ACE) inhibitors appear to correct many of the abnormalities associated with the vascular dysfunction found in diabetic patients. In this respect, quinapril is a unique ACE inhibitor with multiple protective effects. The present study was carried out to investigate the effect of intraperitoneal administration of quinapril on the aortic reactivity of streptozotocin ...

introduction: abusing drugs such as morphine continues to be a serious medical and social problem. defining a habit that increases the devastating effect such as compulsive use and craving is necessary. methods: this experiment was designed in four groups 1) group-housed (gh) 2) isolation 3) group-housed morphine-treated (ghmt) (4) isolated-housed morphine-treated (ihmt). rats were received mor...

The effects of Delonix regia extract (d200mg, d300mg, and d400mg), metformin (m8.3mg, m12.5mg and m16.5mg), pioglitazone (p0.5mg, p0.7mg and p0.9mg) and combined formulation of metformin and extract (m6.25d150mg) on glycated hemoglobin status in streptozotocin-induced diabetic Albino wistar rats. Diabetic status of these rats was assessed by estimating fasting blood glucose levels. A total of 1...

Diabetic rats in long-term display an augmented nociceptive response to chemical, mechanical, and thermal stimuli. Furthermore, hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients. Considering the antidiabetic potential of pepper, this study was conducted to evaluate the possible analgesic effect of pepper-mixed food intake in male streptozotocin-induced diabetic r...

Hypericum species are known to be used in traditional therapies. H. scabrum L. is one of the Hypericum species distributed in Turkey. In this study, we evaluated the effects of Hypericum scabrum essential oil inhalation on spatial memory in scopolamine-induced amnesic rats. The essential oil was characterized by GC-FID and GC-MS system. Male wistar rats were divided into 6 groups: control; scop...

introduction: systemic application of capsaicin to neonatel rodents depletes their primary afferent c-fibers and also results in a wide variety of changes observable in adulthood. the manual methods used for stimulation of vibrissa provide limited information on response properties of barrel cortical neurons. in this study the effect of c-fiber depletion induced by neonatal capsaicin (cap) trea...