Feminists have been heard to say that the late entry of women into the ranks of the medical profession has meant that, left to the tender mercies of mere men, the ills to which female flesh is heir have not been given the attention which they deserved. Our knowledge, for example, of the cause and prevention of mammary carcinoma seems to have made little advance since Ramazzini reported in 1713 ...

Trichomoniasis is one of the most common urinary-genital tract disease. The causal agent of trichomoniasis is flagellate protozoan called Trichomonas vaginalis. Metronidazole and tinidazole are the drug of choice for treatment. Carcinogenic and embryo-teratogenic effects of the mentioned drugs and resistance to metronidazole has been reported. According to cytotoxic effects of medicinal herbs i...

There is some difference of opinion regarding the incidence of vaginal thrush following the treatment of trichomonal vaginitis with the new oral trichomonicide, metronidazole ("Flagyl"). Rees (1960) and Rodin, King, Nicol, and Barrow (1960) concluded that metronidazole neither encouraged nor inhibited the growth of the fungus concerned. Watt and Jennison (1960) found coincident monilial infecti...

Recent studies have demonstrated that the traditional 7-day course of metronidazole at a dosage of 200 mg. three times a day is not the only schedule effective in trichomoniasis (McClean, 1971; Csonka, 1971; Woodcock, 1972). It was decided to assess the efficacy of metronidazole 400 mg. four times a day for 2 days; this dosage would facilitate its administration with tetracycline 500 mg. four t...

A retrospective survey of women treated in prison for trichomonal vaginitis with metronidazole showed that 488 of 496 (98.3%) were cured after one course of drugs. Five of the eight treatment failures were successfully treated by further courses of metronidazole.A regimen of 400 mg metronidazole twice daily for seven days is simple and effective when taken in prescribed dosage. Metronidazole is...

The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of ...

An immunochromatographic strip test, Xenostrip-Tv, was compared to wet mount and PCR for the diagnosis of Trichomonas vaginalis infection in women. Of 428 specimens tested, 54 (12.6%) were positive by an "expanded gold standard," defined as either a positive wet mount and PCR test with primers TVK3 and TVK7 and/or a positive PCR test confirmed by a second PCR assay with primers TVA5-1 and TVA6;...

A series of 868 women in the last 4 weeks of pregnancy were examined for the presence of T. vaginalis by direct microscopy of freshly prepared wet films and by three culture methods; 32 (3-7 per cent.) were found to give positive results. Fourteen of the mothers with trichomoniasis at confinement had female babies, and these, together with a matching fourteen controls, were examined on three oc...