Bottromycin A2 is a structurally unique ribosomally synthesized and post-translationally modified peptide (RiPP) that possesses potent antibacterial activity towards multidrug-resistant bacteria. The structural novelty of bottromycin stems from its unprecedented macrocyclic amidine and rare β-methylated amino acid residues. The N-terminus of a precursor peptide (BtmD) is converted into bottromy...

The study of brain tumor occurs when irregular cells can be appeared within the brain. Therapeutic imaging plays a vital role in the decree of tumors. Previous imaging methods were found offensive and sometimes dangerous, such as pneumonic encephalography and cerebral angiography have been uncontrolled in favor of non-invasive, high-resolution techniques, can be used especially in (MRI). In upc...

These Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date. Over 1740 bacterial genome sequences are currently available in p...

MOTIVATION Key problems for computational genomics include discovering novel pathways in genome data, and discovering functional interaction partners for genes to define new members of partially elucidated pathways. RESULTS We propose a novel method for the discovery of subsystems from annotated genomes. For each gene pair, a score measuring the likelihood that the two genes belong to a same ...

Comparative News Summarization aims to highlight the commonalities and differences between two comparable news topics. In this study, we propose a novel approach to generating comparative news summaries. We formulate the task as an optimization problem of selecting proper sentences to maximize the comparativeness within the summary and the representativeness to both news topics. We consider sem...

We introduce a new system, called shortHMM, for predicting exons, which predicts individual exons using two related genomes. In this system, we build a hidden semi-Markov model to identify exons. In the hidden Markov model, we propose joint probability models of nucleotides in introns, splice sites, 5'UTR, 3'UTR, and intergenic regions by exploiting the homology between related genomes. In orde...

The anti-oxidant activities for a diverse set of flavonoids as TEAC (Trolox equivalent anti-oxidant capacity), assay were subjected to 3D-QSAR (3 dimensional quantitative structural-activity relationship) studies using CoMFA (comparative molecular field analysis) and CoMSIA (comparative molecular similarity indices analysis). The obtained results indicated superiority of CoMSIA model over CoMFA...

in natural gas treatment, the removal of co2 and h2s in acid gases is a critical concern. there are various purification technologies that can be used for the removal of acid gas impurities. absorption of acid gas into amines is one preferred method in gas industries. in the past, single amines was used, but recently in order to improve absorption performance, mixed amines with different solubi...

pistachio is a major agricultural export commodity in iran. nowadays, it ranks first among iran’s agricultural exports. this paper focuses on the comparative advantage in pistachio production and the export market in iran. a policy analysis matrix (pam) framework and revealed comparative advantage (rca) index are applied to 2000-2004 data to study iranian government policy regarding pistachio p...

Mathematical models are widely used to replicate natural phenomena. They represent the growing universe, as well as the spreading of diseases. By concentrating on the essentials of these systems, mathematical models are perfectly suited to study system behavior under altered conditions. Defining a model for a given system is a challenging task and is commonly an advancing process, where current...