Cardiac and vascular diseases represent one of the most substantial medical areas for the applications of regenerative medicine. Despite advances in endovascular repair, surgical intervention, and disease management, atherosclerosis and heart failure continue to be prominent health problems. This report analyzes the regenerative medicine treatment opportunities in both cardiovascular and periph...

background activation of stress response during cardiac surgeries such as cardiopulmonary bypass (cpb) can increase myocardial oxygen demand and consumption through induced tachycardia and augmented peripheral vascular resistance. these physiologic consequences may lead to increased morbidity and mortality by putting too great a strain on the already compromised organ systems. material and meth...

BACKGROUND In experimental animal models, long-term in vivo treatment with nitroglycerin (NTG) induces both endothelial dysfunction and tolerance to nitrates. However, it is still controversial whether nitrate tolerance in humans is associated with both endothelial dysfunction and impaired vascular response to nitrovasodilator-derived NO. METHODS AND RESULTS Patients undergoing elective bypas...

A persistent sciatic artery (PSA) is very rare congenital vascular anomaly which is present in 0.025% to 0.04% of the population by an angiographic study. A PSA is usually combined with aneurismal disease or thromboembolic events because of its arteriosclerosis and vessel wall degeneration. The treatments of symptomatic PSA are comprised of exclusion of PSA from circulation and bypass surgery f...

A heparin-like effect was recently described in infants, children, and adults receiving bivalirudin while supported on extracorporeal membrane oxygenation following cardiopulmonary bypass. This is most likely due to endogenous release of glycosaminoglycans from vascular endothelium and mast cells and is associated with longer duration of extracorporeal membrane oxygenation and an increased inci...

Antiphospholipid syndrome (APS) is a rare disease in which patients display prolonged coagulation test results in vitro, but usually develop thrombotic symptoms in vivo. Patients with APS are at increased risk of valvular heart disease or coronary vascular disease, conditions that often necessitate cardiac surgery via bypass. The management of anticoagulation during cardiopulmonary bypass (CPB)...

Below-The-Knee (BTK) arterial occlusive disease with smalldiameter blood vessels, blood should have low flow from far the way. The disease is often detected when there appear signs of critical limn ischemia. Previously, BTK arterial occlusive disease treatment is often bypass of veins, this is serious surgery that efficiency is not high. Especially in older patients, many factors increase the r...

D espite innovative new techniques in percutaneous transluminal coronary angioplasty (PTCA) during the past 10 years, restenosis rates continue to occur at about 30% in subtotal lesions,' about 50% in chronic total occlusions,2 and up to 80% in saphenous vein bypass grafts.3 Although mortality remains acceptably low, urgent bypass surgery after unsuccessful angioplasty continues to be necessary...

Buerger disease or thromboangiitis obliterans is a non-atherosclerotic, segmental, inflammatory, peripheral arterial occlusive in young male smokers. Revascularization via endovascular treatment and/or bypass surgery less common and technically challenging patients with disease. Herein, we report the case of 30-year-old patient who underwent followed by surgery, which successfully salvaged his c...