This review is based on the Theophilus Redwood Medal and Award lectures, delivered to Royal Society of Chemistry meetings in the UK and Ireland in 2012, and presents a personal overview of the field of biosensors. The biosensors industry is now worth billions of United States dollars, the topic attracts the attention of national initiatives across the world and tens of thousands of papers have ...

t has been nearly 30 years since the first scholars began s t u dying men’s health. Early wo rks had provo c at ive titles like “The Hazards of Being Male”1 and “Socialized to Die Younger.”2 Although these authors stimulated new interest in men’s health, little came of it. It was, perhaps, difficult to sell the idea that men, as a group, were endangered; mortality statistics about their compara...

We present an integrated study of multi-stage hydraulic fracture stimulation of two parallel horizontal wells in the Bakken formation in the Williston Basin, North Dakota. There are two distinct parts of this study: development of a geomechanical model for the study area, and analysis of the microseismic and hydraulic fracturing data. Despite the limited amount of well log data available, we es...

OBJECTIVES To evaluate changes in sexual well being in a group of patients with Parkinson's disease following deep brain stimulation (DBS) of the subthalamic nucleus (STN). METHODS 31 consecutive patients with Parkinson's disease (21 men and 10 women), bilaterally implanted for DBS of STN, were evaluated one month before and 9-12 months after surgery. Sexual functioning was assessed using a r...

Brain stimulation techniques are important in both basic and clinical studies. Majority of well-known brain stimulating techniques have low spatial resolution or entail invasive processes. Low intensity focused ultrasound (LIFU) seems to be a proper candidate for dealing with such deficiencies. This review recapitulates studies which explored the effects of LIFU on brain str...

Brain-derived neurotrophic factor (BDNF) is known to be crucial for the development of peripheral vestibular neurons. However, the maturation profile of the BDNF signal transducing receptor, tyrosine kinase B (TrkB) in functionally activated otolith-related vestibular nuclear neurons of postnatal rats remains unexplored. In the present study, conscious Sprague-Dawley rats (P4 to adult) were sub...

ABSTRACT We analyzed the mechanisms underlying enhanced IgA production in cells of Peyer's patch via membrane vesicles derived from Lactobacillus sakei subsp. NBRC 15893. Depletion CD11c+ suppressed mediated by vesicles. Meanwhile, stimulation bone-marrow–derived dendritic with increased gene expression inducible nitric oxide synthase, retinaldehyde dehydrogenase 2, and several inflammatory cyt...

nasal mucosa has an extraordinary nerve supply with unique geometry that encompasses complex physiology. among these, side-specific predilections to the respiratory and autonomic centers are the interesting issues that have been raised about the consequences of the nasal irritations. the aim of the study was an evaluation of how intranasal stimulation influences lung mechanics and determines wh...