The fiftieth anniversary of Blood saw the publication of a series of excellent review articles. The myeloproliferative disorders [1] were first characterised by Gustav Heuck who described myelofibrosis (MF) in 1879. Louis Henri Vaquez described polycythemia vera (PV) in 1892. Essential thrombocythemia (ET) followed somewhat later in 1934 when Emil Epstein and Alfred Goedel recognised it as a di...

Pruritus is a frequent symptom expressed by patients with myeloproliferative neoplasms (MPN). Aquagenic pruritus (AP) the most emblematic. Incidence, intensity, related symptoms and evolutive risks of have never been extensively studied in MPN patients. MPN-SAF TSS auto-questionnaire was distributed before consultations, to all seen our institution. We collected events from February 2015 Januar...

Since the discovery of JAK2V617F tyrosine kinase-activating mutation, several genes have been found mutated in myeloproliferative neoplasms (MPNs). FLT3-ITD, NPM1, and DNMT3A mutations frequently occurred in AML patients and have been found conferred with myeloproliferative neoplasms in mouse model. Therefore, we sought to search for mutations in JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in 129 cas...

Oysters naturally contaminated with 10(3) to 10(4) most probable numbers (MPN) of Vibrio vulnificus per g were relayed to offshore waters (salinity, 30 to 34 ppt), where they were suspended in racks at a depth of 7.6 m. V. vulnificus counts in oysters were reduced to < 10 MPN/g within 7 to 17 days in five of the six studies. At the end of the studies (17 to 49 days), V. vulnificus levels were r...

Objective. The present study aimed to investigate the presence of vibrios in the hepatopancreas of cultured shrimp. Materials and methods. Vibrios from the hepatopancreas of fifteen samples of five specimens each, of apparently healthy Pacific white shrimp (Litopenaeus vannamei) were isolated, identified and quantified. Results. The vibrio density ranged from 430 to 2,400 MPN g-1 (rs MPN cm-1=-...