The pseudorabies virus (PrV) homolog of the tegument protein encoded by the UL48 gene of herpes simplex virus type 1 (HSV-1) was identified by using a monospecific rabbit antiserum against a bacterial fusion protein. UL48-related polypeptides of 53, 55, and 57 kDa were detected in Western blots of infected cells and purified virions. Immunofluorescence studies demonstrated that the PrV UL48 pro...

The Hox genes encode homeodomain transcription factors that are crucial for body patterning during development. Hox genes exist in clusters and their chromosomal order mimics their spatial and temporal order of expression during embryonic development. This issue's Developmental Biology Select examines recent studies that shed further light on the key roles of Hox genes and their relatives durin...

The present study was mainly conducted to determine whether dietary leucine supplementation could attenuate the decrease of the mucin production in the jejunal mucosa of weaned pigs infected by porcine rotavirus (PRV). A total of 24 crossbred barrows weaned at 21 d of age were assigned randomly to 1 of 2 diets supplemented with 1.00% L-leucine or 0.68% L-alanine (isonitrogenous control) for 17 ...

In vertebrates, sensory specializations are usually correlated with increases in the brain areas associated with that specialization. This correlation is called the 'principle of proper mass' whereby the size of a neural structure is a reflection of the complexity of the behavior that it subserves. In recent years, several comparative studies have revealed examples of this principle in the visu...

Three gilts were vaccinated with a NYVAC vaccinia recombinant expressing glycoprotein gD of pseudorabies virus (PRV) (NYVAC/gD). After farrowing, the piglets were allowed to nurse normally to obtain colostral immunity and then were divided into four groups, receiving NYVAC/gD, a NYVAC recombinant expressing glycoprotein gB of PRV (NYVAC/gB), an inactivated PRV vaccine (iPRV), or no vaccine. The...

Microtubule transport of herpesvirus capsids from the cell periphery to the nucleus is imperative for viral replication and, in the case of many alphaherpesviruses, transmission into the nervous system. Using the neuroinvasive herpesvirus, pseudorabies virus (PRV), we show that the viral protein 1/2 (VP1/2) tegument protein associates with the dynein/dynactin microtubule motor complex and promo...

Dr. P. Harrison, Department of Haematology, Birmingham Heartland’s Hospital, Bordesley Green East, Birmingham B9 5SS (UK) A 74-year-old woman developed polycythaemia rubra vera (PRV) with deletion of the long arm of chromosome 20 (20q-) 11 years after successful treatment of high grade non-Hodgkin’s lymphoma (NHL). The 20qabnormality is a common finding in PRV but has also been described in lym...

The use of sanitizers is essential for produce safety. However, little is known about how sanitizer efficacy varies with respect to the chemical surface properties of produce. To answer this question, the disinfection efficacies of an oxidant-based sanitizer and a new surfactant-based sanitizer for porcine rotavirus (PRV) strain OSU were examined. PRV was attached to the leaf surfaces of two ka...

Envelope glycoproteins gH and gL, which form a complex, are conserved throughout the family Herpesviridae. The gH-gL complex is essential for the fusion between the virion envelope and the cellular cytoplasmic membrane during penetration and is also required for direct viral cell-to-cell spread from infected to adjacent noninfected cells. It has been proposed for several herpesviruses that gL i...