نتایج جستجو برای: فاکتور cox2

تعداد نتایج: 14897  

2017
Dongseong Shin Sook Joung Lee Yu-Mi Ha Young-Sim Choi Jae-Won Kim Se-Rin Park Min Kyu Park

OBJECTIVE Prostaglandin E2 (PGE2) synthesis is modulated by COX2. Changes in PGE2 could be used to quantify the COX2 inhibition after ibuprofen administration. This study investigated the pharmacokinetic and pharmacodynamic relationships for COX2 inhibition according to three formulations of ibuprofen in healthy male subjects. MATERIALS AND METHODS A randomized, open-label, single-dose, three...

2010
Bokai Zhu Robert Bai Mary J. Kennett Boo-Hyon Kang Frank J. Gonzalez Jeffrey M. Peters

Ligand activation of peroxisome proliferator–activated receptor-b/d (PPARb/d) and inhibition of cyclooxygenase-2 (COX2) activity by nonsteroidal anti-inflammatory drugs (NSAID) can both attenuate skin tumorigenesis. The present study examined the hypothesis that combining ligand activation of PPARb/d with inhibition of COX2 activity will increase the efficacy of chemoprevention of chemically in...

Journal: :Infection and immunity 2001
D K Ghosh M A Misukonis C Reich D S Pisetsky J B Weinberg

Depending on sequence, bacterial and synthetic DNAs can activate the host immune system and influence the host response to infection. The purpose of this study was to determine the abilities of various phosphorothioate oligonucleotides with cytosine-guanosine-containing motifs (CpG DNA) to activate macrophages to produce nitric oxide (NO) and prostaglandin E(2) (PGE(2)) and to induce expression...

سابقه و هدف: آرتریت روماتوئید بیماری خودایمنی است که توسط داروهای ضد التهاب غیر استروئیدی درمان میشود. گیاهان دارویی خطرات کمتری نسبت به داروهای شیمیایی دارند یکی از گیاهان مورد استفاده در طب سنتی گیاه سنجد می باشد در مطاله حاضر جهت تائید خاصیت ضد التهابی این گیاه تاثیر عصاره سنجد بر بیان ژنهای COX2 وiNOS دخیل در التهاب مورد بررسی قرار گرفت. مواد و روش‌ها: این مطالعه تجربی بر روی 35 موش صحرایی ...

Journal: :Walailak Journal of Science and Technology 2021

This study aimed to investigate the real-time fluctuation of temperature-sensitive gene expression in a Pythium insidiosum growing at human body temperature (37 ºC) when it can cause life-threatening disease, whereas its natural habitat is agricultural water sources with lower temperature. Genes encoding cytochrome oxidase 2 (COX2), β-tubulin (TUB), and chitin synthase subunit (CHS2) were teste...

2014
Andrea Markkula Maria Simonsson Ann H Rosendahl Alexander Gaber Christian Ingvar Carsten Rose Helena Jernström

The COX2 rs5277 (306G>C) polymorphism has been associated with inflammation-associated cancers. In breast cancer, tumor COX-2 expression has been associated with increased estrogen levels in estrogen receptor (ER)-positive and activated Akt-pathway in ER-negative tumors. Our study investigated the impact of COX2 genotypes on early breast cancer events and treatment response in relation to tumor...

Journal: :Saudi medical journal 2007
Nergis Murat Sedef Gidener Meral Koyuncuoglu Osman Yilmaz

OBJECTIVE To investigate the role of endothelin on nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX2) enzyme inhibitors-induced effects on the gastric mucosa. METHODS This study was carried out in the Department of Pharmacology Laboratory, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey during the period January to December 2002. In the first group ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Ning Li Sandeep Sood Su Wang Mingzhu Fang Peng Wang Zheng Sun Chung S Yang Xiaoxin Chen

PURPOSE Previous studies have suggested an important role of aberrant arachidonic acid metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis. However, it is unknown whether the 5-lipoxygenase (5-Lox) pathway contributes to oral carcinogenesis, and whether combination of inhibitors of both pathways may have synergistic or additive effects of chemoprevention. EXPERIMEN...

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