Recent advances in 3D printing are revolutionizing manufacturing, enabling the fabrication of structures with unprecedented complexity and functionality. Yet biological systems are able to fabricate systems with far greater complexity using a process that involves assembling and folding a linear string. Here, we demonstrate a 1D printing system that uses an approach inspired by the ribosome to ...

We determined the composition of ~30-m.y.-old solutions extracted from fluid inclusions in one of the world's largest and richest silver ore deposits at Fresnillo, Mexico. Silver concentrations average 14 ppm and have a maximum of 27 ppm. The highest silver, lead and zinc concentrations correlate with salinity, consistent with transport by chloro-complexes and confirming the importance of brine...

The tumor suppressor function of PTEN is strongly linked to its ability to dephosphorylate phosphatidylinositol-3,4,5 trisphosphate and, thereby, control cell growth, survival, and migration. However, the mechanism of action of PTEN in living cells is largely unexplored. Here we use single-molecule TIRF microscopy in living cells to reveal that the enzyme binds to the membrane for a few hundred...

We derive an effective 1D theory from the Hamiltonian of the 3D system which consists of a mesoscopic conductor and reservoirs. We assume that the many-body interaction have the same magnitude in the conductor as that in the reservoirs, in contrast to the previous theories which made the ad hoc assumption that the many-body interaction were absent in the reservoirs. We show the following: (i) T...

Cellular automata are used as models of emergent computation and artificial life. They are usually simulated under synchronous and deterministic conditions. Thus, they are evolved without existence of noise, i.e., fluctuation or randomness. However, noise is unavoidable in real world. The target of the present paper is to show the following two effects and several other phenomena caused by exis...

We determined the binding affinity of tamsulosin, a selective α(1)-adrenoceptor antagonist, for human α(1)-adrenoceptor subtypes in comparison with those of other α(1)-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. The association and dissociation kinetics of [(3)H]tamsulosin for recombinant human α(1)-adrenocepto...