The relationship of structural polarity to functional activities was examined in cultured human thyroid follicles, which were isolated from the thyroid gland of patients with Graves' disease by collagenase treatment. Structural polarity was examined morphologically by electron microscopy, while the functional response to bovine TSH was examined by measuring intracellular cAMP accumulation and T...

It has been proposed that neonatal thyroid-stimulating hormone (TSH) concentrations are a good indicator of iodine deficiency in the population. A frequency of neonatal TSH concentrations above 5 mU/L below 3% has been proposed as the threshold indicating iodine sufficiency. The objective of the present study was to evaluate feasibility and usefulness of nation-wide neonatal TSH concentration s...

What is TSH? TSH is produced and secreted by basophilic cells called “thyrotrophs” in the anterior pituitary gland of vertebrates from fishes to mammals. TSH is also called thyrotropic hormone or thyrotropin. TSH acts on thyroid gland, adipose tissue, eye, and so on. TSH receptor penetrates the cell membrane 7 times and is coupled with G-protein-PKA system. TSH increases the release of thyroid ...

BACKGROUND High serum thyroid-stimulating hormone (TSH) is associated with thyroid carcinoma in patients with thyroid nodules. However, previous studies suggests that TSH is not involved in the pathogenesis of small thyroid carcinomas. We performed this study to evaluate serum TSH as a malignancy predictor in the assessment of small thyroid nodules. METHODS We retrospectively analyzed 3791 pa...

background: levothyroxine is commonly used in the treatment of patients with hypothyroidism. levothyroxine is often administered in the morning, on an empty stomach, to increase its absorption. however, many patients have trouble for taking levothyroxine in the morning. the aim of this study was to evaluate the effect of changing administration time of levothyroxine from before breakfast to bef...

Thyroid-stimulating hormone (TSH) regulates the growth and differentiation of thyrocytes by activating the TSH receptor (TSHR). This study investigated the roles of the phosphatidylinositol 3-kinase (PI3K), PDK1, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 (S6K1) signaling mechanism by which TSH and the stimulating type TSHR antibodies regulate thyrocyte proliferation and the ...

OBJECTIVE Remnant ablation with radioactive iodine (I-131) is a successful form of treatment that aims to destroy the remaining residual tissue and/or metastatic tissue after total thyroidectomy in differentiated thyroid cancer (DTC) patients. High level of thyroid stimulating hormone (TSH) (≥30 mIU/L) is recommended for success of ablation treatment. In this retrospective study, our aim was to...

Context The effect of thyrotropin (TSH) suppressive therapy on trabecular bone scores (TBSs) is unclear. Objective The aim of this study was to investigate the effect of TSH suppression on vertebral TBSs of postmenopausal women with differentiated thyroid carcinoma (DTC). Design, Setting, and Participants We conducted a retrospective cohort study including 273 postmenopausal women with DTC ...

Thyrotropin (TSH) has been coupled to the photoactive heterobifunctional reagent N-hydroxysuccinimidyl 4-azidobenzoate (HSAB) and the properties of the product (HSAB-TSH) investigated. Preparations of HSAB-TSH containing two molecules of HSAB per molecule of TSH were used in most experiments and these preparations retained about 40% of the original receptor-binding activity of the TSH. HSAB-TSH...