Cell suspension cultures from hypocotyl-derived callus of Hyssopus officinalis were found to produce two sterols i. e. beta-sitosterol (1) and stigmasterol (2), as well as several known pentacyclic triterpenes with an oleanene and ursene skeleton. The triterpenes were identified as oleanolic acid (3), ursolic acid (4), 2alpha,3beta-dihydroxyolean-12-en-28-oic acid (5), 2alpha,3beta-dihydroxyurs...

دقو .محرلا اموكراس نم نوناعي اضيرم 36 ضارعتسا تم :جئاتنلا دجو دقو ،اَماع 57 ةعومجملل رمعلا طسوتم نأ ريراقتلا تدافأ )19%(7 و carcinosarcoma تلاالحا نم )58%( 21 نأ اموكراس ةيمحللا محرلا ةناطب ،leiomyosarcoma )LMS( 6 يف تصخش )undifferentiated endometrial sarcom( .Rhabdomyosarcoma )RMS( 6% ينتلاحو 17% ىضرم ةثلاثلا ةلحرلما يف تصخش تلاالحا فصن براقي ام نأ دجو دقو يأ ةلاح 15( تناك ينح يف .يلاوتلا ىلع )...

In this study we have profiled the free sterol content of cerebrospinal fluid by a combination of charge tagging and liquid chromatography-tandem mass spectrometry. Surprisingly, the most abundant cholesterol metabolites were found to be C(27) and C(24) intermediates of the bile acid biosynthetic pathways with structures corresponding to 7alpha-hydroxy-3-oxocholest-4-en-26-oic acid (7.170 +/- 2...

INTRODUCTION Opioid-induced constipation (OIC) is the most common side effect of opioid treatment. Treatment for OIC typically involves a laxative. However, some patients have an inadequate response to these (laxative inadequate responders, or LIR). This has led to the development of treatments such as naloxegol. This analysis estimates the impact of naloxegol on the health state utility of LIR...

Opioids are a class of medications frequently used for the treatment of acute and chronic pain, exerting their desired effects at central opioid receptors. Agonism at peripherally located opioid receptors, however, leads to opioid-induced constipation (OIC), one of the most frequent and debilitating side effects of prolonged opioid use. Insufficient relief of OIC with lifestyle modification and...

Five new triterpenoid saponins, fargosides A, B, C, D, and E, were isolated from the roots of Holboellia fargesii. The structures of fargosides A-E were elucidated on the basis of chemical and physicochemical evidence and found to be 3beta,20alpha-dihydroxy-29-norolean-12-en-28-oic acid 3-O-beta-D-xylopyranosyl-(1-->2)-beta-D-glucopyranoside (1), 3beta,20alpha,24-trihydroxy-29-norolean-12-en-28...

تابر مواقم لرتنك هلاقم نيا رد ينيعمان و يجراخ تاشاشتغا دوجو اب رايس ياه متسيس يرتماراپ ياه كيمونولوهريغ يكيتامنيس ديق هك يكيمانيد ١ ار شزغل مدع هدروآرب يمن تسا هتفرگ رارق يسررب دروم ،دننك . هدش زكرمتم يكيتامنيس لرتنك يحارط يور رب هك يلبق ياهراك فلاخرب ساسا رب رواتشگ مواقم رلرتنك كي ،دنا هب ،ميظنت لباق ناسون سناكرف اب اريم كيمانيد رگناسون هناگي شور كي تروص ٢ يبايدر هلأسم ود ره يارب ابر يزا...