Medicinal plants have played a major role in the field of medicine as alternative therapy to orthodox drugs. This present study aimed evaluate acute toxicity Cymbopogon citratus and Origanum vulgare aqueous extracts on albino rats.The qualitative phytochemical analyses was done using standard procedures. The LD50 determined modified Lorke’s method, while biochemical haematological analysis were...

The benzene, alcoholic and aqueous root extracts (75mg/kg each)of Dalbergia spinosa Roxb were studied for its diuretic activity by using male albino rats by adopting the method of Tipschitz. The alcoholic extract increased the urine volume and electrolytes sodium, potassium and chloride, which is similar to the standard drug Furosemide (100mg/ kg) by inhibiting sodium, potassium, and chloride i...

Background Abrupt cessation of most psychiatric drugs leads to varying withdrawal symptoms. Although Clozapine withdrawal symptoms are well documented, this case presentation addresses issues pertaining to the severity of the withdrawals and the similarities to Neuroleptic Malignant Syndrome (NMS). This patient who was only on 100mg of Clozapine required ventilation in Intensive care unit. Neur...

As the brand Epilim, there is a sugar free liquid and oral syrup both containing sodium valproate 200mg in 5ml. It is also available as sodium valproate 100mg crushable tablets, 200mg and 500mg enteric coated tablets and 200mg, 300mg and 500mg modified release tablets. There are also a number of these preparations available as generic formulations both of sodium valproate and valproic acid. It ...

Two green algae (Ulva rigida and Cladophora coelothrix), the mussel Mytilus galloprovincialis and the snail Rapana thomasiana from the Bulgarian Black Sea shore have been treated with diesel fuel (100mg l(-1)) in an aquarium with sea-water for three days. The lipids and their fatty acid changes have been examined. Significant changes have been observed mainly in the polar lipids and in the satu...

A 54-year-old patient had a right mesodiencephalic hemorrhage in 1992, with residual double vision until 2000. He was symptom-free until 2010, when he developed fluctuating diplopia. We observed paroxysmal attacks of a right ocular tilt reaction (OTR) (video at Neurology.org), whereas in the interval he had a left OTR. MRI showed a calcification of the preexisting lesion (figure). The attacks a...

It is sensible to use paracetamol to reduce the discomfort caused by minor acute infections, surgical procedures and triple antigen. It is also sensible to use paracetamol to reduce fever in patients with cardiac or respiratory failure. However, there is little evidence to support the use of paracetamol to treat fever in patients without heart or lung disease, or to prevent febrile convulsions....

To assess the effects of phenytoin sodium on biochemical markers of testicular function. Male Wistar rats (12 weeks old) were treated with phenytoin and sacrificed at the end of 2, 4, 5, 7, 10 and 15 week after the last exposure to phenytoin sodium. The testes were removed, weighed and processed for biochemical analysis. The intratesticular testosterone level was significantly (P<0.001) reduced...

Purpose of the study Darunavir (DRV) is a second generation protease inhibitor (PI), first licensed for use in 2006. It is indicated for use in a treatment experienced population and is effective in vitro against both wild type and PI-resistant HIV. As a relatively new drug there is little published information on the pharmacokinetics of darunavir in pregnancy. Here we examine the pharmacokinet...